Altered retinal cerebral vessel oscillation frequencies in Alzheimer's disease compatible with impaired amyloid clearance

  • Retinal vessels are similar to cerebral vessels in their structure and function. Moderately low oscillation frequencies of around 0.1 Hz have been reported as the driving force for paravascular drainage in gray matter in mice and are known as the frequencies of lymphatic vessels in humans. We aimed to elucidate whether retinal vessel oscillations are altered in Alzheimer's disease (AD) at the stage of dementia or mild cognitive impairment (MCI). Seventeen patients with mild-to-moderate dementia due to AD (ADD); 23 patients with MCI due to AD, and 18 cognitively healthy controls (HC) were examined using Dynamic Retinal Vessel Analyzer. Oscillatory temporal changes of retinal vessel diameters were evaluated using mathematical signal analysis. Especially at moderately low frequencies around 0.1 Hz, arterial oscillations in ADD and MCI significantly prevailed over HC oscillations and correlated with disease severity. The pronounced retinal arterial vasomotion at moderately low frequencies in the ADD and MCI groups would be compatible with the view of a compensatory upregulation of paravascular drainage in AD and strengthen the amyloid clearance hypothesis.

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Author:Konstantin KotliarORCiD, Marion Ortner, Anna Conradi, Patricia Hacker, Christine Hauser, Roman Günthner, Michaela Moser, Claudia Muggenthaler, Janine Diehl-Schmid, Josef Priller, Christoph Schmaderer, Timo Grimmer
DOI:https://doi.org/10.1016/j.neurobiolaging.2022.08.012
ISSN:0197-4580
Parent Title (English):Neurobiology of Aging
Publisher:Elsevier
Place of publication:Amsterdam
Document Type:Article
Language:English
Year of Completion:2022
Tag:Alzheimer's disease; Mild cognitive impairment; Pulsations; Retinal vessel analysis; Vasomotions
Volume:120
First Page:117
Last Page:127
Link:https://doi.org/10.1016/j.neurobiolaging.2022.08.012
Zugriffsart:campus
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / IfB - Institut für Bioengineering
collections:Verlag / Elsevier