Refine
Year of publication
Document Type
- Article (435)
- Conference Proceeding (107)
- Part of a Book (34)
- Book (9)
- Other (4)
- Patent (4)
- Doctoral Thesis (3)
- Talk (1)
Language
- English (597) (remove)
Has Fulltext
- no (597) (remove)
Keywords
- solar sail (5)
- CellDrum (3)
- GOSSAMER-1 (3)
- MASCOT (3)
- Biocomposites (2)
- Iterative learning control (2)
- Limit analysis (2)
- Mars (2)
- Natural fibres (2)
- Polymer-matrix composites (2)
- Shakedown analysis (2)
- Solar sail (2)
- Spacecraft (2)
- Stiffness (2)
- Stress concentrations (2)
- Trajectory Optimization (2)
- bacterial cellulose (2)
- biopotential electrodes (2)
- damage (2)
- locomotion (2)
- multiple NEA rendezvous (2)
- muscle fascicle behavior (2)
- prebiotic (2)
- small spacecraft (2)
- ultrasound (2)
- ultrasound imaging (2)
- Achilles tendon (1)
- Adaptive control (1)
- Ageing (1)
- AlterG (1)
- Alzheimer's disease (1)
- Analogue Environments (1)
- Anastomotic leakage (1)
- Anatomy (1)
- Annulus Fibrosus (1)
- Antarctic Glaciology (1)
- Antarctica (1)
- Architectural gear ratio (1)
- Assistive technology (1)
- Asteroid Deflection (1)
- Attitude dynamics (1)
- Autolysis (1)
- Automated Optimization (1)
- Automatic control (1)
- Bacillus sp (1)
- Biomechanical simulation (1)
- Biosolubilization (1)
- Bladder (1)
- Bone sawing (1)
- Cardiac myocytes (1)
- Cardiac tissue (1)
- Cell permeability (1)
- Cellular force (1)
- Cementoblast (1)
- Chance constrained programming (1)
- Circular Dichroism (1)
- Coefficient of ocular rigidity (1)
- Collagen fibrils (1)
- Compression (1)
- Computational biomechanics (1)
- Connective tissues (1)
- Constitutive model (1)
- Contractile tension (1)
- Corneo-scleral shell (1)
- Cryobot (1)
- DLR-ESTEC GOSSAMER roadmap for solar sailing (1)
- Damage mechanics theory (1)
- Decomposition (1)
- Differential tonometry (1)
- Disc Degeneration (1)
- Discontinuous fractures (1)
- Drug simulation (1)
- Dry surfaces (1)
- EEG (1)
- ES-FEM (1)
- Electromechanical modeling (1)
- End-to-end colorectal anastomosis (1)
- Endothelial cells (1)
- Endothelial dysfunction (1)
- Evolution of damage (1)
- Evolutionary Neurocontrol (1)
- Extension fracture (1)
- Extension strain criterion (1)
- External knee adduction moments (1)
- Extracellular matrix (ECM) (1)
- Extraterrestrial Glaciology (1)
- Eyeball (1)
- FGF23 (1)
- FS-FEM (1)
- Finite element analysis (1)
- Finite element analysis (FEA) (1)
- Finite element modelling (1)
- Force (1)
- Forces (1)
- Fracture configuration (1)
- Fracture simulation (1)
- Freeze–thaw process (1)
- Frequency adaption (1)
- Glaciological instruments and methods (1)
- Glaucoma (1)
- Gossamer (1)
- Gossamer structures (1)
- Growth modelling (1)
- Haemodialysis (1)
- Handbike (1)
- Heart tissue culture (1)
- Hodgkin–Huxley models (1)
- Homogenization (1)
- Human-Computer interaction (1)
- Hybrid Propellants (1)
- Ice Melting (1)
- Ice melting probe (1)
- Ice penetration (1)
- Icy Moons (1)
- Icy moons (1)
- Impedance Spectroscopy (1)
- Induced pluripotent stem cells (1)
- Inotropic compounds (1)
- Interplanetary flight (1)
- Interstellar objects (1)
- Intervertebral Disc (1)
- Intradiscal Pressure (1)
- Inverse dynamic problem (1)
- Inverse kinematic problem (1)
- Ion channels (1)
- Jupiter (1)
- Klotho (1)
- Knee (1)
- LPS (1)
- Lactobacillus rhamnosus GG (1)
- Lipopolysaccharide (1)
- Liver (1)
- Load modeling (1)
- Long COVID (1)
- Low-Thrust Propulsion (1)
- Machine learning (1)
- Manipulated variables (1)
- Mechanical simulation (1)
- Mechanical stability (1)
- Mechanotransduction (1)
- Melting Efficiency (1)
- Melting Performance (1)
- Melting Probe (1)
- Microbial adhesion (1)
- Microcirculation (1)
- Mild cognitive impairment (1)
- Missions (1)
- Mohr–Coulomb criterion (1)
- Multimode failure (1)
- Multiphase (1)
- Muscle (1)
- Muscle Fascicle (1)
- Muscle Force (1)
- Muscle fibers (1)
- Musculoskeletal model (1)
- Musculoskeletal system (1)
- Myocardial infarction and cardiac death (1)
- NONOate (1)
- Niacin (1)
- Nitric Oxide (1)
- Nitric Oxide Donor (1)
- Non-linear optimization (1)
- Non-parallel fissures (1)
- Nucleus Pulposus (1)
- Ocean Worlds (1)
- Ocean worlds (1)
- Ocular blood flow (1)
- Orbital dynamics (1)
- PHILAE (1)
- PTH (1)
- Paralympic sport (1)
- Passive stretching (1)
- Pelvic floor dysfunction (1)
- Pelvic muscle (1)
- Pharmacology (1)
- Phosphate (1)
- Physiology (1)
- Planetary Protection (1)
- Planetary exploration (1)
- Post-COVID-19 syndrome (1)
- Pressure-volume relationship (1)
- Proximal humerus fracture (1)
- Pulsations (1)
- RVA (1)
- Recombinant activated protein C (1)
- Reconstruction (1)
- Rehabilitation Technology and Prosthetics (1)
- Rehabilitation engineering (1)
- Reliability analysis (1)
- Reliability of structures (1)
- Retinal vessel analysis (1)
- Retinal vessels (1)
- Reusable Rocket Engines (1)
- Riboflavin (1)
- Robotic rehabilitation (1)
- Rotator cuff (1)
- Running (1)
- S-FEM (1)
- Sampling methods (1)
- Septic cardiomyopathy (1)
- Sequence-Search (1)
- Simulation (1)
- Sleep EEG (1)
- Small Solar System Body Lander (1)
- Small Spacecraft (1)
- Small spacecraft (1)
- Solar Power Sail (1)
- Solar Sail (1)
- Spacecraft Trajectory Optimization (1)
- Spleen (1)
- Stochastic programming (1)
- Subclacial exploration (1)
- Subglacial lakes (1)
- Surface microorganisms (1)
- Surgical Navigation and Robotics (1)
- Surgical staplers (1)
- Swabbing (1)
- Tapered ends (1)
- Tendon Rupture (1)
- Tendon properties (1)
- Tension (1)
- Thiamine (1)
- Training (1)
- Trajectories (1)
- Uniaxial compression test (1)
- Ureter (1)
- Variable height stapler design (1)
- Vascular response (1)
- Vasomotions (1)
- Visual field asymmetry (1)
- Vitamin A (1)
- Vitamin B (1)
- Vitamin D (1)
- achilles tendon (1)
- actin cytoskeleton (1)
- adipose-derived stromal cells (ASCs) (1)
- adsorption (1)
- agility (1)
- anaesthetic complications (1)
- anisotropy (1)
- aortic perfusion (1)
- asteroid lander (1)
- asteroid sample return (1)
- attitude dynamics (1)
- biaxial tensile experiment (1)
- biofilms (1)
- biomechanics (1)
- carbonized rice husk (1)
- cardiomyocyte biomechanics (1)
- cell aerosolization (1)
- cell atomization (1)
- cerebral small vessel disease (1)
- chance constrained programming (1)
- coculture (1)
- cognitive impairment (1)
- community dwelling (1)
- computational fluid dynamics analysis (1)
- connective tissue (1)
- constitutive modeling (1)
- constructive alignment (1)
- correlation (1)
- crop yield (1)
- dental trauma (1)
- dialysis (1)
- difficult airway (1)
- distorted element (1)
- double-lumen tube intubation (1)
- drop jump (1)
- electromyography (1)
- endoluminal (1)
- energy absorption (1)
- energy dissipation (1)
- examination (1)
- exopolysaccharides (1)
- extracorporeal membrane oxygenation (1)
- flotilla missions (1)
- force generation (1)
- forehead EEG (1)
- gait (1)
- habitability (1)
- healthy aging (1)
- heliosphere (1)
- hiPS cardiomyocytes (1)
- high-intensity exercise (1)
- humic acid (1)
- hyper-gravity (1)
- hyperelastic (1)
- hypo-gravity (1)
- ice moons (1)
- icy moons (1)
- immobilization (1)
- impedance spectroscopy (1)
- in-ear EEG (1)
- intraclass correlation coefficient (1)
- ion propulsion (1)
- life detection (1)
- lignite (1)
- limit analysis (1)
- lipopolysaccharide (1)
- long-term retention (1)
- low-rank coal (1)
- low-thrust (1)
- low-thrust trajectory optimization (1)
- mechanical buffer (1)
- multimodal (1)
- muscle mechanics (1)
- near-Earth asteroid (1)
- non-simplex S-FEM elements (1)
- orbit control (1)
- orbital dynamics (1)
- overload (1)
- parabolic flight (1)
- performance testing (1)
- physiology (1)
- planetary defence (1)
- practical learning (1)
- prevention (1)
- psychosocial (1)
- pullulan (1)
- rehabilitation (1)
- reliability of structures (1)
- responsive space (1)
- retinal microvasculature (1)
- retinal vessels (1)
- running (1)
- sEMG (1)
- sailcraft (1)
- sample return (1)
- sarcomere operating length (1)
- sensors (1)
- series elastic element behavior (1)
- shakedown analysis (1)
- shoulder (1)
- simulation (1)
- small solar system body characterisation (1)
- small spacecraft asteroid lander (1)
- small spacecraft solar sail (1)
- smooth muscle contraction (1)
- soil amendment (1)
- soil health (1)
- soil remediation (1)
- solar sails (1)
- solar system (1)
- space missions (1)
- sprint start (1)
- standard error of measurement (1)
- stiffness (1)
- stochastic programming (1)
- strain energy function (1)
- stretch reflex (1)
- stretch-shortening cycle (1)
- surface modification (1)
- survival (1)
- system engineering (1)
- tendon rupture (1)
- test-retest reliability (1)
- training simulator (1)
- tri-lineage differentiation (1)
- twin-fluid atomizer (1)
- ultrasonography (1)
- underwater vehicle (1)
- unloading (1)
- videolaryngoscopy (1)
- virgin passive (1)
- virtual reality (1)
- viscoelasticity (1)
- walking (1)
- walking gait (1)
Optical coherence tomography : a potential tool to predict premature rupture of fetal membranes
(2013)
Background
True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN).
Results
Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm.
Conclusions
Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1% and reached 100% in one of the best ANN.
Changes in intestinal microflora in rats induced by oral exposure to low lead (II) concentrations
(2015)
Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model
(2020)
Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5% and 50nM verapamil by 2,8%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.
On the model of musculocutaneous wound in rats, the effect of applicative sorption by carbonized rise shell (CRS) on the healing of festering wound was studied. It has been shown, that cytological changes end with rapid scar formation. The use of CRS at the period of severe purulent wound contributes to its favorable course, prevents the development of complications of the animals from sepsis.
The CellDrum technology (The term 'CellDrum technology' includes a couple of slightly different technological setups for measuring lateral mechanical tension in various types of cell monolayers or 3D-tissue constructs) was designed to quantify the contraction rate and mechanical tension of self-exciting cardiac myocytes. Cells were grown either within flexible, circular collagen gels or as monolayer on top of respective 1-mum thin silicone membranes. Membrane and cells were bulged outwards by air pressure. This biaxial strain distribution is rather similar the beating, blood-filled heart. The setup allowed presetting the mechanical residual stress level externally by adjusting the centre deflection, thus, mimicking hypertension in vitro. Tension was measured as oscillating differential pressure change between chamber and environment. A 0.5-mm thick collagen-cardiac myocyte tissue construct induced after 2 days of culturing (initial cell density 2 x 10(4) cells/ml), a mechanical tension of 1.62 +/- 0.17 microN/mm(2). Mechanical load is an important growth regulator in the developing heart, and the orientation and alignment of cardiomyocytes is stress sensitive. Therefore, it was necessary to develop the CellDrum technology with its biaxial stress-strain distribution and defined mechanical boundary conditions. Cells were exposed to strain in two directions, radially and circumferentially, which is similar to biaxial loading in real heart tissues. Thus, from a biomechanical point of view, the system is preferable to previous setups based on uniaxial stretching.
Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.
Reconstructive surgery and tissue replacements like ureters or bladders reconstruction have been recently studied, taking into account growth and remodelling of cells since living cells are capable of growing, adapting, remodelling or degrading and restoring in order to deform and respond to stimuli. Hence, shapes of ureters or bladders and their microstructure change during growth and these changes strongly depend on external stimuli such as training. We present the mechanical stimulation of smooth muscle cells in a tubular fibrin-PVDFA scaffold and the modelling of the growth of tissue by stimuli. To this end, mechanotransduction was performed with a kyphoplasty balloon catheter that was guided through the lumen of the tubular structure. The bursting pressure was examined to compare the stability of the incubated tissue constructs. The results showed the significant changes on tissues with training by increasing the burst pressure as a characteristic mechanical property and the smooth muscle cells were more oriented with uniformly higher density. Besides, the computational growth models also exhibited the accurate tendencies of growth of the cells under different external stimuli. Such models may lead to design standards for the better layered tissue structure in reconstructing of tubular organs characterized as composite materials such as intestines, ureters and arteries.