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  • Peter Linder (37)
  • Ilya Digel (25)
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Institute

  • IfB - Institut für Bioengineering (36)
  • Fachbereich Medizintechnik und Technomathematik (35)
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Alterations in human hemoglobin structure related to red blood cell storage (2011)
Rasha Bassam ; Gerhard Artmann ; Jürgen Hescheler ; T. Graef ; Aysegül Temiz Artmann ; Dariusz Porst ; Peter Linder ; Peter Kayser ; Vladimir Arinkin ; Matthias Gossmann ; Ilya Digel
The importance of the availability of stored blood or blood cells, respectively, for urgent transfusion cannot be overestimated. Nowadays, blood storage becomes even more important since blood products are used for epidemiological studies, bio-technical research or banked for transfusion purposes. Thus blood samples must not only be processed, stored, and shipped to preserve their efficacy and safety, but also all parameters of storage must be recorded and reported for Quality Assurance. Therefore, blood banks and clinical research facilities are seeking more accurate, automated means for blood storage and blood processing.
Engineering technology for plant physiology and plant stress research (2011)
C. Preiß ; Peter Linder ; K. Wendt ; M. Krystek ; Ilya Digel ; Matthias Gossmann ; Aysegül Temiz Artmann ; Dariusz Porst ; Peter Kayser ; Rasha Bassam ; Gerhard Artmann
Plant physiology and plant stress: Plant physiology will be much more important for human mankind because of yield and cultivation limits of crops determined by their resistance to stress. To assess and counteract various stress factors it is necessary to conduct plant research to gain information and results on plant physiology.
Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds (2011)
Volker Seifarth ; D. Schehl ; Peter Linder ; Matthias Gossmann ; Ilya Digel ; Gerhard Artmann ; Dariusz Porst ; C. Preiß ; Peter Kayser ; O. Pack ; Aysegül Temiz Artmann
The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 %. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days.
Biophysical and Engineering Contributions to Plant Research (2011)
Gerhard Artmann ; Ilya Digel ; Peter Linder ; Aysegül Temiz Artmann
Tests with palm tree leaves have just started yet and scan data are in the process to be analyzed. The final goal of future project for palm tree gender and species recognition will be to develop optical scanning technology to be applied to date palm tree leaves for in–situ screening purposes. Depending on the software used and the particular requirements of the users the technology potentially shall be able to identify palm tree diseases, palm tree gender, and species of young date palm trees by scanning leaves.
rhAPC reduces the endothelial cell permeability via a decrease of cellular mechanical contractile tensions : [abstract] (2010)
Eylem Kurulgan Demirci ; Peter Linder ; Taylan Demirci ; Jessica R. Gierkowski ; Ilya Digel ; Matthias Gossmann ; Aysegül Temiz Artmann
In this study, the CellDrum technology quanitfying cellular mechanical tension on a pico-scale was used to investigate the effect of LPS (lipopolysaccharide) on HAoEC (Human Aortic Endothelial Cell) tension.
In-situ biological decontamination of an ice melting probe : [abstract] (2010)
Ilya Digel ; W. Leimena ; Bernd Dachwald ; Peter Linder ; Dariusz Porst ; Peter Kayser ; O. Funke ; Aysegül Temiz Artmann ; Gerhard Artmann
The objective of our study was to investigate the efficacy of different in-situ decontamination protocols in the conditions of thermo-mechanical ice-melting.
A concept of a probe for particle analysis and life detection in icy environments (2009)
Ilya Digel ; Bernd Dachwald ; Gerhard Artmann ; Peter Linder ; O. Funke
A melting probe equipped with autofluorescence-based detection system combined with a light scattering unit, and, optionally, with a microarray chip would be ideally suited to probe icy environments like Europa’s ice layer as well as the polar ice layers of Earth and Mars for recent and extinct live.
Fibroblast response to mechanical stress: role of the adhesion substrate : [abstract] (2004)
Ilya Digel ; Taylan Demirci ; Jürgen Trzewik ; Peter Linder ; Aysegül Temiz Artmann
Mechanical stimulation of the cells resulted in evident changes in the cell morphology, protein composition and gene expression. Microscopically, additional formation of stress fibers accompanied by cell re-arrangements in a monolayer was observed. Also, significant activation of p53 gene was revealed as compared to control. Interestingly, the use of CellTech membrane coating induced cell death after mechanical stress had been applied. Such an effect was not detected when fibronectin had been used as an adhesion substrate.
NMR in vitro effects on proliferation, apoptosis, and viability of human chondrocytes and osteoblasts (2005)
Aysegül Temiz Artmann ; Peter Linder ; Peter Kayser ; Ilya Digel
Hemoglobin senses body temperature (2009)
Gerhard Artmann ; Ilya Digel ; Kay Zerlin ; Christina Maggakis-Kelemen ; Peter Linder ; Dariusz Porst ; Peter Kayser ; David Stadler ; Gerhard Dikta ; Aysegül Temiz Artmann
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