Refine
Year of publication
- 2020 (227) (remove)
Document Type
- Article (124)
- Conference Proceeding (55)
- Part of a Book (16)
- Book (9)
- Review (7)
- Doctoral Thesis (3)
- Other (3)
- Patent (3)
- Administrative publication (3)
- Contribution to a Periodical (1)
- Part of Periodical (1)
- Poster (1)
- Report (1)
Language
- English (157)
- German (68)
- Multiple languages (1)
- nld (1)
Keywords
- Amtliche Mitteilung (3)
- MINLP (3)
- Additive manufacturing (2)
- Adjacent buildings (2)
- Experimental validation (2)
- Historical centres (2)
- INODIS (2)
- SIJ (2)
- Shake table test (2)
- Solar-Institut Jülich (2)
- Stone masonry (2)
- Verwaltungs- und Benutzungsordnung (2)
- 3D printing (1)
- Acceptance (1)
- Adaptive control (1)
- Anwendungsorientierter Forschungsansatz (1)
- Aufhebungsordnung (1)
- Biofuel (1)
- Biorefinery (1)
- Blind prediction competition (1)
Institute
- Fachbereich Medizintechnik und Technomathematik (52)
- Fachbereich Energietechnik (34)
- IfB - Institut für Bioengineering (33)
- Fachbereich Luft- und Raumfahrttechnik (31)
- Fachbereich Wirtschaftswissenschaften (31)
- Fachbereich Elektrotechnik und Informationstechnik (29)
- ECSM European Center for Sustainable Mobility (17)
- Fachbereich Maschinenbau und Mechatronik (17)
- Fachbereich Bauingenieurwesen (14)
- Fachbereich Chemie und Biotechnologie (13)
- Solar-Institut Jülich (13)
- INB - Institut für Nano- und Biotechnologien (12)
- Institut fuer Angewandte Polymerchemie (7)
- MASKOR Institut für Mobile Autonome Systeme und Kognitive Robotik (6)
- Nowum-Energy (6)
- FH Aachen (4)
- IBB - Institut für Baustoffe und Baukonstruktionen (3)
- IaAM - Institut für angewandte Automation und Mechatronik (3)
- Arbeitsstelle fuer Hochschuldidaktik und Studienberatung (1)
- Fachbereich Architektur (1)
Die Energiewirtschaft befindet sich in einem starken Wandel, der v. a. durch die Energiewende und Digitalisierung Druck auf sämtliche Marktteilnehmer ausübt. Das klassische Geschäftsmodell des Energieversorgungsunternehmens verändert sich dabei grundlegend. Der kontinuierlich ansteigende Einsatz dezentraler und volatiler Erzeugungsanlagen macht die Identifikation von Flexibilitätspotenzialen notwendig, um weiterhin eine hohe Versorgungssicherheit zu gewährleisten. Dieser Schritt ist nur mit einem hohen Digitalisierungsgrad möglich. Eine funktionale Plattform mit Microservices, die zu Geschäftsprozessen verbunden werden können, wird als Möglichkeit zur Aktivierung der Flexibilität und Digitalisierung der Energieversorgungsunternehmen im Folgenden vorgestellt.
Die Durchführung einer systematischen Literaturrecherche ist eine zentrale Kompetenz wissenschaftlichen Arbeitens und bildet daher einen festen Ausbildungsbestandteil von Bachelor- und Masterstudiengängen. In entsprechenden Lehrveranstaltungen werden Studierende zwar mit den grundlegenden Hilfsmitteln zur Suche und Verwaltung von Literatur vertraut gemacht, allerdings werden die Potenziale textanalytischer Methoden und Anwendungssysteme (Text Mining, Text Analytics) dabei zumeist nicht abgedeckt. Folglich werden Datenkompetenzen, die zur systemgestützten Analyse und Erschließung von Literaturdaten erforderlich sind, nicht hinreichend ausgeprägt. Um diese Kompetenzlücke zu adressieren, ist an der Hochschule Osnabrück eine Lehrveranstaltung konzipiert und projektorientiert umgesetzt worden, die sich insbesondere an Studierende wirtschaftswissenschaftlicher Studiengänge richtet. Dieser Beitrag dokumentiert die fachliche sowie technische Ausgestaltung dieser Veranstaltung und zeigt Potenziale für die künftige Weiterentwicklung auf.
Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model
(2020)
Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5% and 50nM verapamil by 2,8%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.
The problem of creation and use of sorption materials is of current interest for the practice of the modern medicine and agriculture. Practical importance is production of a biostimulant using a carbon sorbent for a significant increase in productivity, which is very relevant for the regions of Kazakhstan. It is known that a plant phytohormone—fusicoccin—in nanogram concentrations transforms cancer cells to the state of apoptosis. In this regard, there is a scientific practical interest in the development of a highly efficient method for producing fusicoccin from extract of germinated wheat seeds. According to the results of computer modeling, cleaning composite components of fusicoccin using microporous carbon adsorbents not suitable as the size of the molecule of fusicoccin more than micropores and the optimum pore size for purification of constituents of fusicoccin was determined by computer simulation.
The treatment of septic wounds with curative dressings based on biocomposites containing sage and marigold phytoextracts was effective in in vitro and in vivo experiments. These dressings caused the purification of the wound surface from purulent-necrotic masses three days earlier than in the other experimental groups. The consequence of an increase in incidents of severe course of the wound and the observed tendency to increase the number of adverse effects is the development of long-term recurrent wound processes. To treat purulent wounds, the following tactics were used: The purulent wounds of animals were covered with the examined wound dressing, and then the next day samples were taken, the procedure was performed once in 2 days. To obtain the active nanostructured sorbents such as carbonized rice husks, they are functionalized with biologically active components possessing antimicrobial, anti-inflammatory, antitoxic, immunomodulating, antiallergic and other types of properties.
There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords “vitamin D,” “intestines,” “gut microflora,” “bowel inflammation”. Only articles published in English and related to the study topic are included in the review. We discuss how vitamin D (a) modulates intestinal microbiome function, (b) controls antimicrobial peptide expression, and (c) has a protective effect on epithelial barriers in the gut mucosa. Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. Metabolites from the gut microbiota may also regulate expression of VDR, while vitamin D may influence the gut microbiota and exert anti-inflammatory and immune-modulating effects. The underlying mechanism of vitamin D in the pathogenesis of bowel diseases is not fully understood, but maintaining an optimal vitamin D status appears to be beneficial for gut health. Future studies will shed light on the molecular mechanisms through which vitamin D and VDR interactions affect intestinal mucosal immunity, pathogen invasion, symbiont colonization, and antimicrobial peptide expression.
Humic substances originating from various organic matters can ameliorate soil properties, stimulate plant growth, and improve nutrient uptake. Due to the low calorific heating value, leonardite is rather unsuitable as fuel. However, it may serve as a potential source of humic substances. This study was aimed at characterizing the leonardite-based soil amendments and examining the effect of their application on the soil microbial community, as well as on potato growth and tuber yield. A high yield (71.1%) of humic acid (LHA) from leonardite has been demonstrated. Parental leonardite (PL) and LHA were applied to soil prior to potato cultivation. The 16S rRNA sequencing of soil samples revealed distinct relationships between microbial community composition and the application of leonardite-based soil amendments. Potato tubers were planted in pots in greenhouse conditions. The tubers were harvested at the mature stage for the determination of growth and yield parameters. The results demonstrated that the LHA treatments had a significant effect on increasing potato growth (54.9%) and tuber yield (66.4%) when compared to the control. The findings highlight the importance of amending leonardite-based humic products for maintaining the biogeochemical stability of soils, for keeping their healthy microbial community structure, and for increasing the agronomic productivity of potato plants.