Refine
Year of publication
Institute
- Fachbereich Energietechnik (57)
- Fachbereich Elektrotechnik und Informationstechnik (56)
- Fachbereich Luft- und Raumfahrttechnik (21)
- Solar-Institut Jülich (17)
- Fachbereich Medizintechnik und Technomathematik (12)
- ECSM European Center for Sustainable Mobility (10)
- Fachbereich Maschinenbau und Mechatronik (8)
- Fachbereich Wirtschaftswissenschaften (5)
- IfB - Institut für Bioengineering (4)
- INB - Institut für Nano- und Biotechnologien (3)
Has Fulltext
- no (184) (remove)
Document Type
- Article (93)
- Conference Proceeding (38)
- Book (31)
- Part of a Book (17)
- Conference: Meeting Abstract (2)
- Bachelor Thesis (1)
- Patent (1)
- Report (1)
Keywords
- Literaturanalyse (3)
- Digitale Transformation (2)
- Digitalisierung (2)
- Forschungsprozess (2)
- Robotic Process Automation (2)
- Text Analytics (2)
- cyber physical production system (2)
- digital shadow (2)
- Antarctica (1)
- Arbeit 4.0 (1)
- Chatbots (1)
- Customer Experience Management (1)
- Customer Journeys (1)
- E-Learning (1)
- EBSCO Discovery Service (1)
- Emotional (1)
- Enterprise Architecture (1)
- Forschung (1)
- Forschungsinformationssystem (1)
- Fotografie (1)
- Fühlen (1)
- Geschäftsmodelle (1)
- IBM Watson Explorer (1)
- Image Database (1)
- Image Forensics (1)
- Informationsgetriebene Geschäftsmodelle (1)
- Intelligentes Parken (1)
- Internet der Dinge (1)
- Jupiter (1)
- Kommerzielle Interaktionen (1)
- Literatur-analyse-prozess (1)
- Literaturdaten (1)
- Literature review (1)
- Literaturrecherche (1)
- Mobile Phones (1)
- Monetarisierung (1)
- Planetary exploration (1)
- Portrait (1)
- Prozessagilität (1)
- Prozessautomatisierung (1)
- Qualitative Wertschöpfungsanalyse (1)
- Research process (1)
- Serviceintegration (1)
- Software Robots (1)
- Text Analytics (1)
- Text Mining (1)
- Text analytics (1)
- Text mining (1)
- Unternehmensarchitekturen (1)
- Unternehmensarchitekturen Internet der Dinge (1)
- Weiblicher Blick (1)
- Wertschöpfungskettenanalyse (1)
- Wissenstransfer (1)
- anaesthetic complications (1)
- business process automation (1)
- commercial offthe- shelf solutions (1)
- cyber-physical production system (1)
- dental trauma (1)
- difficult airway (1)
- digital twin (1)
- double-lumen tube intubation (1)
- human digital shadow (1)
- human factors (1)
- human-machine interface (1)
- ice moons (1)
- internet of production (1)
- robotic process automation (1)
- software evaluation (1)
- software selection (1)
- underwater vehicle (1)
- user & usage (1)
- videolaryngoscopy (1)
A High-Throughput Functional Complementation Assay for Classification of BRCA1 Missense Variants
(2013)
The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.
Inkompressible Strömungen
(2015)
Operational Modal Analysis (OMA) is a promising candidate for flutter testing and Structural Health Monitoring (SHM) of aircraft wings that are passively excited by wind loads. However, no studies have been published where OMA is tested in transonic flows, which is the dominant condition for large civil aircraft and is characterized by complex and unique aerodynamic phenomena. We use data from the HIRENASD large-scale wind tunnel experiment to automatically extract modal parameters from an ambiently excited wing operated in the transonic regime using two OMA methods: Stochastic Subspace Identification (SSI) and Frequency Domain Decomposition (FDD). The system response is evaluated based on accelerometer measurements. The excitation is investigated from surface pressure measurements. The forcing function is shown to be non-white, non-stationary and contaminated by narrow-banded transonic disturbances. All these properties violate fundamental OMA assumptions about the forcing function. Despite this, all physical modes in the investigated frequency range were successfully identified, and in addition transonic pressure waves were identified as physical modes as well. The SSI method showed superior identification capabilities for the investigated case. The investigation shows that complex transonic flows can interfere with OMA. This can make existing approaches for modal tracking unsuitable for their application to aircraft wings operated in the transonic flight regime. Approaches to separate the true physical modes from the transonic disturbances are discussed.