Refine
Year of publication
Document Type
- Article (3149)
- Conference Proceeding (1016)
- Part of a Book (184)
- Book (144)
- Doctoral Thesis (30)
- Patent (25)
- Other (9)
- Report (9)
- Preprint (4)
- Poster (3)
- Talk (3)
- Master's Thesis (2)
- Working Paper (2)
- Bachelor Thesis (1)
- Contribution to a Periodical (1)
- Habilitation (1)
Language
- English (4583) (remove)
Has Fulltext
- no (4583) (remove)
Keywords
- Gamification (6)
- avalanche (6)
- Earthquake (5)
- Enterprise Architecture (5)
- MINLP (5)
- solar sail (5)
- Diversity Management (4)
- Energy storage (4)
- Engineering optimization (4)
- LAPS (4)
- Natural language processing (4)
- Papierkunst (4)
- Power plants (4)
- Seismic design (4)
- field-effect sensor (4)
- frequency mixing magnetic detection (4)
- hydrogen (4)
- metal structure (4)
- snow (4)
- steel (4)
Institute
- Fachbereich Medizintechnik und Technomathematik (1545)
- Fachbereich Elektrotechnik und Informationstechnik (686)
- IfB - Institut für Bioengineering (560)
- Fachbereich Energietechnik (552)
- INB - Institut für Nano- und Biotechnologien (532)
- Fachbereich Chemie und Biotechnologie (522)
- Fachbereich Luft- und Raumfahrttechnik (463)
- Fachbereich Maschinenbau und Mechatronik (261)
- Fachbereich Wirtschaftswissenschaften (196)
- Solar-Institut Jülich (160)
- Fachbereich Bauingenieurwesen (146)
- ECSM European Center for Sustainable Mobility (75)
- MASKOR Institut für Mobile Autonome Systeme und Kognitive Robotik (62)
- Fachbereich Gestaltung (24)
- Nowum-Energy (24)
- Institut fuer Angewandte Polymerchemie (23)
- Sonstiges (21)
- Fachbereich Architektur (20)
- Freshman Institute (18)
- Kommission für Forschung und Entwicklung (18)
The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of gene expression. Here, we have investigated the temporal sequence of molecular and pathological perturbations at early stages of phenobarbital (PB) mediated liver tumor promotion in vivo. Molecular profiling (mRNA, microRNA [miRNA], DNA methylation, and proteins) of mouse liver during 13 weeks of PB treatment revealed progressive increases in hepatic expression of long noncoding RNAs and miRNAs originating from the Dlk1-Dio3 imprinted gene cluster, a locus that has recently been associated with stem cell pluripotency in mice and various neoplasms in humans. PB induction of the Dlk1-Dio3 cluster noncoding RNA (ncRNA) Meg3 was localized to glutamine synthetase-positive hypertrophic perivenous hepatocytes, sug- gesting a role for β-catenin signaling in the dysregulation of Dlk1-Dio3 ncRNAs. The carcinogenic relevance of Dlk1-Dio3 locus ncRNA induction was further supported by in vivo genetic dependence on constitutive androstane receptor and β-catenin pathways. Our data identify Dlk1-Dio3 ncRNAs as novel candidate early biomarkers for mouse liver tumor promotion and provide new opportunities for assessing the carcinogenic potential of novel compounds.
Objectives
To assess the image quality of T2-weighted (T2w) magnetic resonance imaging of the prostate and the visibility of prostate cancer at 7 Tesla (T).
Materials & methods
Seventeen prostate cancer patients underwent T2w imaging at 7T with only an external transmit/receive array coil. Three radiologists independently scored images for image quality, visibility of anatomical structures, and presence of artefacts. Krippendorff’s alpha and weighted kappa statistics were used to assess inter-observer agreement. Visibility of prostate cancer lesions was assessed by directly linking the T2w images to the confirmed location of prostate cancer on histopathology.
Results
T2w imaging at 7T was achievable with ‘satisfactory’ (3/5) to ‘good’ (4/5) quality. Visibility of anatomical structures was predominantly scored as ‘satisfactory’ (3/5) and ‘good’ (4/5). If artefacts were present, they were mostly motion artefacts and, to a lesser extent, aliasing artefacts and noise. Krippendorff’s analysis revealed an α = 0.44 between three readers for the overall image quality scores. Clinically significant cancer lesions in both peripheral zone and transition zone were visible at 7T.
Conclusion
T2w imaging with satisfactory to good quality can be routinely acquired, and cancer lesions were visible in patients with prostate cancer at 7T using only an external transmit/receive body array coil.