Refine
Year of publication
- 2024 (2)
- 2023 (1)
- 2022 (9)
- 2021 (6)
- 2020 (8)
- 2019 (13)
- 2018 (17)
- 2017 (10)
- 2016 (15)
- 2015 (9)
- 2014 (4)
- 2013 (8)
- 2012 (14)
- 2011 (1)
- 2010 (6)
- 2009 (2)
- 2008 (5)
- 2007 (4)
- 2006 (1)
- 2005 (2)
- 2004 (3)
- 2003 (6)
- 2002 (3)
- 2000 (4)
- 1999 (2)
- 1998 (1)
- 1997 (2)
- 1996 (2)
- 1995 (1)
- 1993 (3)
- 1992 (1)
- 1991 (2)
- 1990 (1)
- 1989 (1)
- 1988 (1)
- 1987 (2)
- 1985 (1)
Document Type
- Article (117)
- Conference Proceeding (31)
- Part of a Book (13)
- Book (4)
- Other (3)
- Report (2)
- Doctoral Thesis (1)
- Patent (1)
- Review (1)
Has Fulltext
- no (173) (remove)
Keywords
- Biocomposites (2)
- Limit analysis (2)
- Natural fibres (2)
- Polymer-matrix composites (2)
- Shakedown analysis (2)
- Stress concentrations (2)
- damage (2)
- Anastomotic leakage (1)
- Autolysis (1)
- Bladder (1)
- Bone sawing (1)
- Cardiac myocytes (1)
- Cardiac tissue (1)
- CellDrum (1)
- Chance constrained programming (1)
- Collagen fibrils (1)
- Computational biomechanics (1)
- Connective tissues (1)
- Constitutive model (1)
- Damage mechanics theory (1)
Biomechanical simulation of different prosthetic meshes for repairing uterine/vaginal vault prolapse
(2017)
In this paper we propose a stochastic programming method to analyse limit and shakedown of structures under uncertainty condition of strength. Based on the duality theory, the shakedown load multiplier formulated by the kinematic theorem is proved actually to be the dual form of the shakedown load multiplier formulated by static theorem. In this investigation a dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit and the shakedown limit. The edge-based smoothed finite element method (ES-FEM) with three-node linear triangular elements is used for structural analysis.
Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.
We present an electromechanically coupled computational model for the investigation of a thin cardiac tissue construct consisting of human-induced pluripotent stem cell-derived atrial, ventricular and sinoatrial cardiomyocytes. The mechanical and electrophysiological parts of the finite element model, as well as their coupling are explained in detail. The model is implemented in the open source finite element code Code_Aster and is employed for the simulation of a thin circular membrane deflected by a monolayer of autonomously beating, circular, thin cardiac tissue. Two cardio-active drugs, S-Bay K8644 and veratridine, are applied in experiments and simulations and are investigated with respect to their chronotropic effects on the tissue. These results demonstrate the potential of coupled micro- and macroscopic electromechanical models of cardiac tissue to be adapted to experimental results at the cellular level. Further model improvements are discussed taking into account experimentally measurable quantities that can easily be extracted from the obtained experimental results. The goal is to estimate the potential to adapt the presented model to sample specific cell cultures.
Plate osteosynthesis of displaced proximal phalangeal neck fractures of the hand allows early mobilization due to a stable internal fixation. Nevertheless, joint stiffness—because of soft tissue irritation—represents a common complication leading to high complication rates. Del Pinal et al. recently reported promising clinical results for a new, minimally invasive fixation technique with a cannulated headless intramedullary compression screw. Hence, the aim of this study was to compare plate fixation of proximal phalangeal neck fractures to less two less invasive techniques: Crossed k-wire fixation and intramedullary screw fixation. We hypothesized that these fixation techniques provide inferior stability when compared to plate osteosynthesis.