Refine
Year of publication
- 2017 (254) (remove)
Document Type
- Article (108)
- Conference Proceeding (85)
- Part of a Book (33)
- Book (13)
- Other (11)
- Report (2)
- Doctoral Thesis (1)
- Patent (1)
Has Fulltext
- no (254) (remove)
Keywords
- Autonomous mobile robots (2)
- Gamification (2)
- Industry 4.0 (2)
- MASCOT (2)
- Multi-robot systems (2)
- Smart factory (2)
- 3D nonlinear finite element model (1)
- Acceptance tests (1)
- Ausfachungsmauerwerk (1)
- Automated Optimization (1)
- Bein (1)
- Bewertungsframework (1)
- Biomolecular logic gate (1)
- CNOT (1)
- Capacitive field-effect (1)
- Chemical images (1)
- Chemical sensor (1)
- Chimeric liver-humanized mice (1)
- Competence Developing Gam (1)
- Competence Developing Games (1)
Institute
- Fachbereich Medizintechnik und Technomathematik (66)
- Fachbereich Elektrotechnik und Informationstechnik (37)
- IfB - Institut für Bioengineering (34)
- Fachbereich Luft- und Raumfahrttechnik (32)
- Fachbereich Wirtschaftswissenschaften (32)
- Fachbereich Energietechnik (27)
- INB - Institut für Nano- und Biotechnologien (27)
- Fachbereich Maschinenbau und Mechatronik (23)
- Fachbereich Bauingenieurwesen (14)
- Fachbereich Chemie und Biotechnologie (12)
- MASKOR Institut für Mobile Autonome Systeme und Kognitive Robotik (12)
- Fachbereich Architektur (10)
- Solar-Institut Jülich (6)
- ZHQ - Bereich Hochschuldidaktik und Evaluation (6)
- ECSM European Center for Sustainable Mobility (5)
- Institut fuer Angewandte Polymerchemie (4)
- Fachbereich Gestaltung (2)
- IBB - Institut für Baustoffe und Baukonstruktionen (1)
- Kommission für Forschung und Entwicklung (1)
- Nowum-Energy (1)
Extrem hohe Blitzströme
(2017)
Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.
Gearboxes are mechanical transmission systems that provide speed and torque conversions from a rotating power source. Being a central element of the drive train, they are relevant for the efficiency and durability of motor vehicles. In this work, we present a new approach for gearbox design: Modeling the design problem as a mixed-integer nonlinear program (MINLP) allows us to create gearbox designs from scratch for arbitrary requirements and—given enough time—to compute provably globally optimal designs for a given objective. We show how different degrees of freedom influence the runtime and present an exemplary solution.
A laser-enhanced solar sail is a solar sail that is not solely propelled by solar radiation but additionally by a laser beam that illuminates the sail. This way, the propulsive acceleration of the sail results from the combined action of the solar and the laser radiation pressure onto the sail. The potential source of the laser beam is a laser satellite that coverts solar power (in the inner solar system) or nuclear power (in the outer solar system) into laser power. Such a laser satellite (or many of them) can orbit anywhere in the solar system and its optimal orbit (or their optimal orbits) for a given mission is a subject for future research. This contribution provides the model for an ideal laser-enhanced solar sail and investigates how a laser can enhance the thrusting capability of such a sail. The term ”ideal” means that the solar sail is assumed to be perfectly reflecting and that the laser beam is assumed to have a constant areal power density over the whole sail area. Since a laser beam has a limited divergence, it can provide radiation pressure at much larger solar distances and increase the radiation pressure force into the desired direction. Therefore, laser-enhanced solar sails may make missions feasible, that would otherwise have prohibitively long flight times, e.g. rendezvous missions in the outer solar system. This contribution will also analyze exemplary mission scenarios and present optimial trajectories without laying too much emphasis on the design and operations of the laser satellites. If the mission studies conclude that laser-enhanced solar sails would have advantages with respect to ”traditional” solar sails, a detailed study of the laser satellites and the whole system architecture would be the second next step
The scientific interest in near-Earth asteroids (NEAs) and the classification of some of those as potentially hazardous asteroid for the Earth stipulated the interest in NEA exploration. Close-up observations of these objects will increase drastically our knowledge about the overall NEA population. For this reason, a multiple NEA rendezvous mission through solar sailing is investigated, taking advantage of the propellantless nature of this groundbreaking propulsion technology. Considering a spacecraft based on the DLR/ESA Gossamer technology, this work focuses on the search of possible sequences of NEA encounters. The effectiveness of this approach is demonstrated through a number of fully-optimized trajectories. The results show that it is possible to visit five NEAs within 10 years with near-term solar-sail technology. Moreover, a study on a reduced NEA database demonstrates the reliability of the approach used, showing that 58% of the sequences found with an approximated trajectory model can be converted into real solar-sail trajectories. Lastly, this second study shows the effectiveness of the proposed automatic optimization algorithm, which is able to find solutions for a large number of mission scenarios without any input required from the user.
Following the successful PHILAE landing with ESA's ROSETTA probe and the launch of the MINERVA rovers and the Mobile Asteroid Surface Scout, MASCOT, aboard the JAXA space probe, HAYABUSA2, to asteroid (162173) Ryugu, small landers have found increasing interest. Integrated at the instrument level in their mothership they support small solar system body studies. With efficient capabilities, resource-friendly design and inherent robustness they are an attractive exploration mission element. We discuss advantages and constraints of small sub-spacecraft, focusing on emerging areas of activity such as asteroid diversity studies, planetary defence, and asteroid mining, on the background of our projects PHILAE, MASCOT, MASCOT2, the JAXA-DLR Solar Power Sail Lander Design Study, and others. The GOSSAMER-1 solar sail deployment concept also involves independent separable sub-spacecraft operating synchronized to deploy the sail. Small spacecraft require big changes in the way we do things and occasionally a little more effort than would be anticipated based on a traditional large spacecraft approach. In a Constraints-Driven Engineering environment we apply Concurrent Design and Engineering (CD/CE), Concurrent Assembly, Integration and Verification (CAIV) and Model-Based Systems Engineering (MBSE). Near-term solar sails will likely be small spacecraft which we expect to harmonize well with nano-scale separable instrument payload packages.