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Capacitive Field-Effect Biosensor Studying Adsorption of Tobacco Mosaic Virus Particles

  • Plant virus-like particles, and in particular, tobacco mosaic virus (TMV) particles, are increasingly being used in nano- and biotechnology as well as for biochemical sensing purposes as nanoscaffolds for the high-density immobilization of receptor molecules. The sensitive parameters of TMV-assisted biosensors depend, among others, on the density of adsorbed TMV particles on the sensor surface, which is affected by both the adsorption conditions and surface properties of the sensor. In this work, Ta₂O₅-gate field-effect capacitive sensors have been applied for the label-free electrical detection of TMV adsorption. The impact of the TMV concentration on both the sensor signal and the density of TMV particles adsorbed onto the Ta₂O₅-gate surface has been studied systematically by means of field-effect and scanning electron microscopy methods. In addition, the surface density of TMV particles loaded under different incubation times has been investigated. Finally, the field-effect sensor also demonstrates the label-free detection of penicillinase immobilization as model bioreceptor on TMV particles.

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Author:Melanie Jablonski, Arshak PoghossianORCiD, Robin Severin, Michael Keusgen, Christian Wege, Michael Josef SchöningORCiD
Parent Title (English):Micromachines
Place of publication:Basel
Document Type:Article
Year of Completion:2021
Date of the Publication (Server):2021/01/13
Tag:TMV adsorption; Ta₂O₅ gate; capacitive field-effect sensor; plant virus detection; tobacco mosaic virus (TMV)
Length:Artikel 57
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / INB - Institut für Nano- und Biotechnologien
collections:Verlag / MDPI
Open Access / Gold
Licence (German):License LogoCreative Commons - Namensnennung