Multiplexing system for automated characterization of a capacitive field-effect sensor array
- In comparison to single-analyte devices, multiplexed systems for a multianalyte detection offer a reduced assay time and sample volume, low cost, and high throughput. Herein, a multiplexing platform for an automated quasi-simultaneous characterization of multiple (up to 16) capacitive field-effect sensors by the capacitive–voltage (C–V) and the constant-capacitance (ConCap) mode is presented. The sensors are mounted in a newly designed multicell arrangement with one common reference electrode and are electrically connected to the impedance analyzer via the base station. A Python script for the automated characterization of the sensors executes the user-defined measurement protocol. The developed multiplexing system is tested for pH measurements and the label-free detection of ligand-stabilized, charged gold nanoparticles.
| Author: | Tobias KarschuckORCiD, Stefan Schmidt, Stefan AchtsnichtORCiD, Arshak Poghossian, Patrick Wagner, Michael Josef SchöningORCiD |
|---|---|
| DOI: | https://doi.org/10.1002/pssa.202300265 |
| ISSN: | 1862-6300 (Print) |
| ISSN: | 1862-6319 (Online) |
| Parent Title (English): | Physica Status Solidi A |
| Publisher: | Wiley-VCH |
| Place of publication: | Weinheim |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2023 |
| Date of the Publication (Server): | 2023/12/01 |
| Tag: | Capacitive field-effect sensor; Gold nanoparticles; Label-free detection; Multicell; Multiplexing |
| Volume: | 220 |
| Issue: | 22 |
| Length: | 7 Seiten |
| Note: | Corresponding author: Michael Josef Schöning |
| Link: | https://doi.org/10.1002/pssa.202300265 |
| Zugriffsart: | weltweit |
| Institutes: | FH Aachen / Fachbereich Medizintechnik und Technomathematik |
| FH Aachen / INB - Institut für Nano- und Biotechnologien | |
| collections: | Verlag / Wiley-VCH |
| Open Access / Hybrid | |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell |
