Susanne Angermann, Roman Günthner, Henner Hanssen, Georg Lorenz, Matthias C. Braunisch, Dominik Steubl, Julia Matschkal, Stephan Kemmner, Renate Hausinger, Zenonas Block, Bernhard Haller, Uwe Heemann, Konstantin Kotliar, Timo Grimmer, Christoph Schmaderer
- Objective
Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels.
Methods
152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions.
Results
In unadjusted as well as in adjusted linear regression analyses a significant association between the visuospatial executive function domain score of the Montreal Cognitive Assessment and the maximum arteriolar dilation as response of retinal arterioles to the flicker light stimulation was obtained.
Conclusion
This is the first study determining retinal microvascular function as surrogate for cerebral microvascular function and cognition in hemodialysis patients. The relationship between impairment in executive function and reduced arteriolar reaction to flicker light stimulation supports the involvement of cerebral small vessel disease as contributing factor for the development of cognitive impairment in this patient population and might be a target for noninvasive disease monitoring and therapeutic intervention.
MetadatenVerfasserangaben: | Susanne Angermann, Roman GünthnerORCiD, Henner Hanssen, Georg Lorenz, Matthias C. Braunisch, Dominik Steubl, Julia Matschkal, Stephan Kemmner, Renate Hausinger, Zenonas Block, Bernhard Haller, Uwe Heemann, Konstantin KotliarORCiD, Timo Grimmer, Christoph Schmaderer |
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DOI: | https://doi.org/10.1002/mpr.1909 |
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ISSN: | 1049-8931 (Print) |
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ISSN: | 1557-0657 (Online) |
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Titel des übergeordneten Werkes (Englisch): | International Journal of Methods in Psychiatric Research (MPR) |
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Verlag: | Wiley |
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Dokumentart: | Wissenschaftlicher Artikel |
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Sprache: | Englisch |
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Erscheinungsjahr: | 2022 |
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Datum der Erstveröffentlichung: | 15.03.2022 |
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Datum der Publikation (Server): | 26.01.2023 |
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Freies Schlagwort / Tag: | cerebral small vessel disease; cognitive impairment; dialysis; retinal vessels |
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Jahrgang: | 31 |
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Ausgabe / Heft: | 2 |
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Erste Seite: | 1 |
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Letzte Seite: | 10 |
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Link: | Online lesen |
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Zugriffsart: | weltweit |
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Fachbereiche und Einrichtungen: | FH Aachen / Fachbereich Medizintechnik und Technomathematik |
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| FH Aachen / IfB - Institut für Bioengineering |
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open_access (DINI-Set): | open_access |
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collections: | Verlag / Wiley |
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| Open Access / Gold |
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Lizenz (Deutsch): | Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung |
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