Development of a tool to analyze the conduction speed in microelectrode array measurements of cardiac tissue
- The discovery of human induced pluripotent stem cells reprogrammed from somatic cells [1] and their ability to differentiate into cardiomyocytes (hiPSC-CMs) has provided a robust platform for drug screening [2]. Drug screenings are essential in the development of new components, particularly for evaluating the potential of drugs to induce life-threatening pro-arrhythmias. Between 1988 and 2009, 14 drugs have been removed from the market for this reason [3]. The microelectrode array (MEA) technique is a robust tool for drug screening as it detects the field potentials (FPs) for the entire cell culture. Furthermore, the propagation of the field potential can be examined on an electrode basis. To analyze MEA measurements in detail, we have developed an open-source tool.
Author: | Jan Hunker, Alexander JungORCiD, Matthias GoßmannORCiD, Peter LinderORCiD, Manfred StaatORCiD |
---|---|
DOI: | https://doi.org/10.17185/duepublico/48750 |
ISBN: | 978-3-940402-22-6 |
Parent Title (English): | 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen |
Publisher: | Universität Duisburg-Essen |
Place of publication: | Duisburg |
Editor: | Manfred StaatORCiD, Daniel Erni |
Document Type: | Conference Proceeding |
Language: | English |
Year of Completion: | 2019 |
Creating Corporation: | MedTech Symposium |
Contributing Corporation: | Young Researchers Academy |
First Page: | 7 |
Last Page: | 8 |
Link: | https://doi.org/10.17185/duepublico/48750 |
Institutes: | FH Aachen / Fachbereich Medizintechnik und Technomathematik |
FH Aachen / IfB - Institut für Bioengineering | |
open_access (DINI-Set): | open_access |
collections: | Verlag / Universität Duisburg-Essen |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung |