Coupling of Biomolecular Logic Gates with Electronic Transducers: From Single Enzyme Logic Gates to Sense/Act/Treat Chips

  • The integration of biomolecular logic principles with electronic transducers allows designing novel digital biosensors with direct electrical output, logically triggered drug-release, and closed-loop sense/act/treat systems. This opens new opportunities for advanced personalized medicine in the context of theranostics. In the present work, we will discuss selected examples of recent developments in the field of interfacing enzyme logic gates with electrodes and semiconductor field-effect devices. Special attention is given to an enzyme OR/Reset logic gate based on a capacitive field-effect electrolyte-insulator-semiconductor sensor modified with a multi-enzyme membrane. Further examples are a digital adrenaline biosensor based on an AND logic gate with binary YES/NO output and an integrated closed-loop sense/act/treat system comprising an amperometric glucose sensor, a hydrogel actuator, and an insulin (drug) sensor.

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Metadaten
Author:Denise MolinnusORCiD, Arshak PoghossianORCiD, Michael Keusgen, Evgeny Katz, Michael Josef SchöningORCiD
DOI:https://doi.org/10.1002/elan.201700208
ISSN:1521-4109
Parent Title (English):Electroanalysis
Publisher:Wiley
Place of publication:Weinheim
Document Type:Article
Language:English
Year of Completion:2017
Volume:29
Issue:8
First Page:1840
Last Page:1849
Link:https://doi.org/10.1002/elan.201700208
Zugriffsart:campus
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / INB - Institut für Nano- und Biotechnologien
collections:Verlag / Wiley