Layer-specific damage modeling of porcine large intestine under biaxial tension

  • The mechanical behavior of the large intestine beyond the ultimate stress has never been investigated. Stretching beyond the ultimate stress may drastically impair the tissue microstructure, which consequently weakens its healthy state functions of absorption, temporary storage, and transportation for defecation. Due to closely similar microstructure and function with humans, biaxial tensile experiments on the porcine large intestine have been performed in this study. In this paper, we report hyperelastic characterization of the large intestine based on experiments in 102 specimens. We also report the theoretical analysis of the experimental results, including an exponential damage evolution function. The fracture energies and the threshold stresses are set as damage material parameters for the longitudinal muscular, the circumferential muscular and the submucosal collagenous layers. A biaxial tensile simulation of a linear brick element has been performed to validate the applicability of the estimated material parameters. The model successfully simulates the biomechanical response of the large intestine under physiological and non-physiological loads.

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Metadaten
Author:Aroj BhattaraiORCiD, Charlotte Anabell May, Manfred StaatORCiD, Wojciech Kowalczyk, Thanh Ngoc TranORCiD
DOI:https://doi.org/10.3390/bioengineering9100528
ISSN:2306-5354
Parent Title (English):Bioengineering
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Year of Completion:2022
Tag:anisotropy; biaxial tensile experiment; constitutive modeling; damage; hyperelastic
Volume:9
Issue:10, Early Access
First Page:1
Last Page:17
Note:
Der Artikel gehört zum Sonderheft "Computational Biomechanics"
Link:https://doi.org/10.3390/bioengineering9100528
Zugriffsart:weltweit
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / IfB - Institut für Bioengineering
open_access (DINI-Set):open_access
collections:Verlag / MDPI
Open Access / Gold
Licence (German): Creative Commons - Namensnennung