Virgin passive colon biomechanics and a literature review of active contraction constitutive models

  • The objective of this paper is to present our findings on the biomechanical aspects of the virgin passive anisotropic hyperelasticity of the porcine colon based on equibiaxial tensile experiments. Firstly, the characterization of the intestine tissues is discussed for a nearly incompressible hyperelastic fiber-reinforced Holzapfel–Gasser–Ogden constitutive model in virgin passive loading conditions. The stability of the evaluated material parameters is checked for the polyconvexity of the adopted strain energy function using positive eigenvalue constraints of the Hessian matrix with MATLAB. The constitutive material description of the intestine with two collagen fibers in the submucosal and muscular layer each has been implemented in the FORTRAN platform of the commercial finite element software LS-DYNA, and two equibiaxial tensile simulations are presented to validate the results with the optical strain images obtained from the experiments. Furthermore, this paper also reviews the existing models of the active smooth muscle cells, but these models have not been computationally studied here. The review part shows that the constitutive models originally developed for the active contraction of skeletal muscle based on Hill’s three-element model, Murphy’s four-state cross-bridge chemical kinetic model and Huxley’s sliding-filament hypothesis, which are mainly used for arteries, are appropriate for numerical contraction numerical analysis of the large intestine.

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Metadaten
Author:Aroj BhattaraiORCiD, Andreas HorbachORCiD, Manfred StaatORCiD, Wojciech Kowalczyk, Thanh Ngoc TranORCiD
DOI:https://doi.org/10.3390/biomechanics2020013
ISSN:2673-7078
Parent Title (English):Biomechanics
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Year of Completion:2022
Tag:damage; smooth muscle contraction; strain energy function; virgin passive; viscoelasticity
Volume:2
Issue:2
First Page:138
Last Page:157
Link:https://doi.org/10.3390/biomechanics2020013
Zugriffsart:weltweit
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / IfB - Institut für Bioengineering
collections:Verlag / MDPI
Open Access / Gold