Elsevier
Refine
Year of publication
- 2017 (22) (remove)
Document Type
- Article (21)
- Part of a Book (1)
Keywords
- CNOT (1)
- Capacitive field-effect (1)
- Chemical images (1)
- Chemical sensor (1)
- Chimeric liver-humanized mice (1)
- Dehydrogenase (1)
- Diaphorase (1)
- Drug distribution (1)
- Drug metabolism (1)
- Dry-low-NOx (DLN) combustion (1)
- EIS capacitive sensor (1)
- Electrolyte–insulator–semiconductor (1)
- Enzymatic biosensor (1)
- Enzyme logic gate (1)
- High hydrogen combustion (1)
- Hydrogen combustion (1)
- Hydrogen gas turbine (1)
- Knockout mice (1)
- LAPS (1)
- Light-addressable potentiometric sensor (1)
Institute
- Fachbereich Medizintechnik und Technomathematik (13)
- INB - Institut für Nano- und Biotechnologien (10)
- Fachbereich Chemie und Biotechnologie (5)
- Fachbereich Luft- und Raumfahrttechnik (3)
- IfB - Institut für Bioengineering (3)
- Fachbereich Bauingenieurwesen (2)
- ECSM European Center for Sustainable Mobility (1)
- Fachbereich Elektrotechnik und Informationstechnik (1)
- Fachbereich Energietechnik (1)
- Institut fuer Angewandte Polymerchemie (1)
- Solar-Institut Jülich (1)
Hotelling’s T² tests in paired and independent survey samples are compared using the traditional asymptotic efficiency concepts of Hodges–Lehmann, Bahadur and Pitman, as well as through criteria based on the volumes of corresponding confidence regions. Conditions characterizing the superiority of a procedure are given in terms of population canonical correlation type coefficients. Statistical tests for checking these conditions are developed. Test statistics based on the eigenvalues of a symmetrized sample cross-covariance matrix are suggested, as well as test statistics based on sample canonical correlation type coefficients.
Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.
The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice
(2017)
The immobilization of NAD+-dependent dehydrogenases, in combination with a diaphorase, enables the facile development of multiparametric sensing devices. In this work, an amperometric biosensor array for simultaneous determination of ethanol, formate, d- and l-lactate is presented. Enzyme immobilization on platinum thin-film electrodes was realized by chemical cross-linking with glutaraldehyde. The optimization of the sensor performance was investigated with regard to enzyme loading, glutaraldehyde concentration, pH, cofactor concentration and temperature. Under optimal working conditions (potassium phosphate buffer with pH 7.5, 2.5 mmol L-1 NAD+, 2.0 mmol L-1 ferricyanide, 25 °C and 0.4% glutaraldehyde) the linear working range and sensitivity of the four sensor elements was improved. Simultaneous and cross-talk free measurements of four different metabolic parameters were performed successfully. The reliable analytical performance of the biosensor array was demonstrated by application in a clarified sample of inoculum sludge. Thereby, a promising approach for on-site monitoring of fermentation processes is provided.