Refine
Year of publication
- 2016 (268) (remove)
Document Type
- Article (116)
- Conference Proceeding (80)
- Part of a Book (27)
- Book (23)
- Other (10)
- Report (5)
- Doctoral Thesis (3)
- Part of Periodical (2)
- Patent (1)
- Talk (1)
Keywords
- Technical Operations Research (2)
- Additive Manufacturing (1)
- Annulus Fibrosus (1)
- Assessment (1)
- Asymptotic efficiency (1)
- Bacillus atrophaeus (1)
- Balance (1)
- Balanced hypergraph (1)
- Brandfall (1)
- Building Systems (1)
- Business Simulations (1)
- Cardiac myocytes (1)
- Cardiac tissue (1)
- CellDrum (1)
- Censored data (1)
- Co-managed care (1)
- Collaborative robot (1)
- Computational biomechanics (1)
- Controller Parameter (1)
- DNA biosensor (1)
- Designpraxis (1)
- Disc Degeneration (1)
- Diversity (1)
- Drinking Water Supply (1)
- Drug simulation (1)
- Duality (1)
- EN 1993-1-2 (1)
- Effizienz (1)
- Einbetten in das Internet der Dinge (1)
- Elderly (1)
- Electromechanical modeling (1)
- Engineering Education (1)
- Eutectic Silver Copper alloy (1)
- External knee adduction moments (1)
- Fall prevention (1)
- Field effect (1)
- Forschung, pränormativ (1)
- Frequency adaption (1)
- Gamification (1)
- Gender (1)
- Ground-level falls (1)
- Hall’s Theorem (1)
- Heart tissue culture (1)
- Higher Education (1)
- Hodgkin–Huxley models (1)
- Homogenization (1)
- Human-Robot interaction (1)
- Hypergraph (1)
- Hypothesentests (1)
- Induced pluripotent stem cells (1)
- Inotropic compounds (1)
- Intervertebral Disc (1)
- Intradiscal Pressure (1)
- Inverse dynamic problem (1)
- Inverse kinematic problem (1)
- Ion channels (1)
- Koenig’s Theorem (1)
- LAPS (1)
- Label-free detection (1)
- Layer-by-layer adsorption (1)
- Level Control System (1)
- Manipulated variables (1)
- Matching (1)
- Minimal-Ansatz für Embedded-Systeme (1)
- Mixed Integer Programming (1)
- Mixed-Integer Nonlinear Optimisation (1)
- Mobility (1)
- Mobility tests (1)
- Musculoskeletal model (1)
- Nucleus Pulposus (1)
- Optimal Closed Loop (1)
- Optimal Topology (1)
- Optimization (1)
- Parametric Design (1)
- Parametric Modelling (1)
- Path planning (1)
- Pharmacology (1)
- Poly(allylamine hydrochloride) (1)
- Porositat (1)
- Product-integration (1)
- Reference Process Model (1)
- Referenzmodellierung (1)
- Response Surface Method (1)
- SLM (1)
- Safety concept (1)
- Semi-parametric random censorship model (1)
- Serious Games (1)
- Solver Per- formance (1)
- Structuralist Architecture (1)
- Subject-oriented Business Process Management (1)
- Survival analysis (1)
- System Design (1)
- System Design Problem (1)
- TM Forum (1)
- TTIP (1)
- Technical Operation Research (1)
- Telecommunications Industry. (1)
- Tinetti test (1)
- Tragwerksbemessung (1)
- Unternehmensarchitektur (1)
- Unternehmenstransformation (1)
- Vergleich von Experimenten (1)
- Vertex cover (1)
- Volterra integral equation (1)
- Workspace monitoring (1)
- biosensors (1)
- building industry (1)
- chemical sensor (1)
- diversity (1)
- eTOM (1)
- efficiency (1)
- electronic communications markets (1)
- endospores (1)
- energy disspation (1)
- engineering education (1)
- enhanced Telecom Operations Map (eTOM) (1)
- friction (1)
- hiPS cardiomyocytes (1)
- immobilization (1)
- impulsive effects (1)
- industrial research (1)
- ingot (1)
- innovation (1)
- iron and steel industry (1)
- liberalisation (1)
- light-addressable potentiometric sensor (1)
- liquid-storage tank (1)
- liquid-structure interaction (1)
- materials technology (1)
- metal structure (1)
- organosilanes (1)
- plug-based microfluidic device (1)
- regulation (1)
- research project (1)
- research report (1)
- resistance of materials (1)
- seismic response (1)
- silanization (1)
- social responsible engineering (1)
- steel (1)
- structural design (1)
- structure-soil-structure interaction (1)
- testing hypotheses (1)
- wave run-up (1)
Institute
- Fachbereich Medizintechnik und Technomathematik (54)
- Fachbereich Chemie und Biotechnologie (36)
- Fachbereich Bauingenieurwesen (35)
- Fachbereich Elektrotechnik und Informationstechnik (35)
- IfB - Institut für Bioengineering (35)
- Fachbereich Wirtschaftswissenschaften (31)
- Fachbereich Luft- und Raumfahrttechnik (27)
- Fachbereich Maschinenbau und Mechatronik (25)
- Fachbereich Energietechnik (17)
- INB - Institut für Nano- und Biotechnologien (15)
- MASKOR Institut für Mobile Autonome Systeme und Kognitive Robotik (11)
- Institut fuer Angewandte Polymerchemie (5)
- Nowum-Energy (5)
- Solar-Institut Jülich (5)
- ZHQ - Bereich Hochschuldidaktik und Evaluation (5)
- ECSM European Center for Sustainable Mobility (4)
- Fachbereich Architektur (4)
- FH Aachen (2)
- IBB - Institut für Baustoffe und Baukonstruktionen (2)
- Fachbereich Gestaltung (1)
Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.
Elastomers are exceptional materials owing to their ability to undergo large deformations before failure. However, due to their very low stiffness, they are not always suitable for industrial applications. Addition of filler particles provides reinforcing effects and thus enhances the material properties that render them more versatile for applications like tyres etc. However, deformation behavior of filled polymers is accompanied by several nonlinear effects like Mullins and Payne effect. To this day, the physical and chemical changes resulting in such nonlinear effect remain an active area of research. In this work, we develop a heterogeneous (or multiphase) constitutive model at the mesoscale explicitly considering filler particle aggregates, elastomeric matrix and their mechanical interaction through an approximate interface layer. The developed constitutive model is used to demonstrate cluster breakage, also, as one of the possible sources for Mullins effect observed in non-crystallizing filled elastomers.
Für die Verarbeitung von natürlicher Sprache ist ein wichtiger Zwischenschritt das Parsing, bei dem für Sätze der natürlichen Sprache Ableitungsbäume bestimmt werden. Dieses Verfahren ist vergleichbar zum Parsen formaler Sprachen, wie z. B. das Parsen eines Quelltextes. Die Parsing-Methoden der formalen Sprachen, z. B. Bottom-up-Parser, können nicht auf das Parsen der natürlichen Sprache übertragen werden, da keine Formalisierung der natürlichen Sprachen existiert [3, 12, 23, 30].
In den ersten Programmen, die natürliche Sprache verarbeiten [32, 41], wurde versucht die natürliche Sprache mit festen Regelmengen zu verarbeiten. Dieser Ansatz stieß jedoch schnell an seine Grenzen, da die Regelmenge nicht vollständig sowie nicht minimal ist und wegen der benötigten Menge an Regeln schwer zu verwalten ist. Die Korpuslinguistik [22] bot die Möglichkeit, die Regelmenge durch Supervised-Machine-Learning-Verfahren [2] abzulösen.
Teil der Korpuslinguistik ist es, große Textkorpora zu erstellen und diese mit sprachlichen Strukturen zu annotieren. Zu diesen Strukturen gehören sowohl die Wortarten als auch die Ableitungsbäume der Sätze. Vorteil dieser Methodik ist es, dass repräsentative Daten zur Verfügung stehen. Diese Daten werden genutzt, um mit Supervised-Machine-Learning-Verfahren die Gesetzmäßigkeiten der natürliche Sprachen zu erlernen.
Das Maximum-Entropie-Verfahren ist ein Supervised-Machine-Learning-Verfahren, das genutzt wird, um natürliche Sprache zu erlernen. Ratnaparkhi [25] nutzt Maximum-Entropie, um Ableitungsbäume für Sätze der natürlichen Sprache zu erlernen. Dieses Verfahren macht es möglich, die natürliche Sprache (abgebildet als Σ∗) trotz einer fehlenden formalen Grammatik zu parsen.
Hintergrund
Die Anwendung und das Verständnis von Statistik sind sehr wichtig für die biomedizinische Forschung und für die klinische Praxis. Dies gilt insbesondere auch zur Abschätzung der Möglichkeiten unterschiedlichster Diagnostik- und Therapieoptionen beim Glaukom. Die scheinbare Komplexität der Statistik, die zum Teil dem „gesunden Menschenverstand“ zu widersprechen scheint, zusammen mit der nur vorsichtigen Akzeptanz der Statistik bei vielen Medizinern können zu bewussten und unbewussten Manipulationen bei der Datendarstellung und -interpretation führen.
Ziel der Arbeit
Ziel ist die verständliche Darstellung einiger typischer Fehler in der medizinisch-statistischen Datenbehandlung.
Material und Methoden
Anhand hypothetischer Beispiele aus der Glaukomdiagnostik erfolgen die Darstellung der Wirkung eines hypotensiven Medikamentes sowie die Beurteilung der Ergebnisse eines diagnostischen Tests. Es werden die typischsten statistischen Einsatzbereiche und Irrtumsquellen ausführlich und verständlich analysiert
Ergebnisse
Mechanismen von Datenmanipulation und falscher Dateninterpretation werden aufgeklärt. Typische Irrtumsquellen bei der statistischen Auswertung und Datendarstellung werden dabei erläutert.
Schlussfolgerungen
Die erläuterten praktischen Beispiele zeigen die Notwendigkeit, die Grundlagen der Statistik zu verstehen und korrekt anwenden zu können. Fehlendes Grundlagenwissen und Halbwissen der medizinischen Statistik können zu folgenschweren Missverständnissen und falschen Entscheidungen in der medizinischen Forschung, aber auch in der klinischen Praxis führen.
We present an effective and simple multiscale method for equilibrating Kremer Grest model polymer melts of varying stiffness. In our approach, we progressively equilibrate the melt structure above the tube scale, inside the tube and finally at the monomeric scale. We make use of models designed to be computationally effective at each scale. Density fluctuations in the melt structure above the tube scale are minimized through a Monte Carlo simulated annealing of a lattice polymer model. Subsequently the melt structure below the tube scale is equilibrated via the Rouse dynamics of a force-capped Kremer-Grest model that allows chains to partially interpenetrate. Finally the Kremer-Grest force field is introduced to freeze the topological state and enforce correct monomer packing. We generate 15 melts of 500 chains of 10.000 beads for varying chain stiffness as well as a number of melts with 1.000 chains of 15.000 monomers. To validate the equilibration process we study the time evolution of bulk, collective, and single-chain observables at the monomeric, mesoscopic, and macroscopic length scales. Extension of the present method to longer, branched, or polydisperse chains, and/or larger system sizes is straightforward.
The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept.
This paper describes the procedure on the evaluation of the masonry chapter for the next generation of Eurocode 8, the European Standard for earthquake-resistant design. In CEN, TC 250/SC8, working group WG 1 has been established to support the subcommittee on the topic of masonry on both design of new structures (EN1998-1) and assessment of existing structures (EN1998-3). The aim is to elaborate suggestions for amendments which fit the current state of the art in masonry and earthquake-resistant design. Focus will be on modelling, simplified methods, linear-analysis (q-values, overstrength-values), nonlinear procedures, out-of-plane design as well as on clearer definition of limit states. Beside these, topics related to general material properties, reinforced masonry, confined masonry, mixed structures and non-structural infills will be covered too. This paper presents the preliminary work and results up to the submission date.