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Effect of plasma treatment on the sensor properties of a light‐addressable potentiometric sensor (LAPS) (2019)
Dua Özsoylu ; Sefa Kizildag ; Michael J. Schöning ; Torsten Wagner
Differential chemical imaging of extracellular acidification within microfluidic channels using a plasma-functionalized light-addressable potentiometric sensor (LAPS) (2020)
Dua Özsoylu ; Sefa Kizildag ; Michael J. Schöning ; Torsten Wagner
Systematische Erfassung der Beständigkeit von Ryton-, P84- und Dralon ATF 1063-Fasern unter Einwirkung verschiedener NOx-Konzentrationen in einem definierten Temperaturintervall (1991)
S. Özdil ; Heinz Berndt ; Hartwig Höcker
Modification of HPV 16 E7 genes: correlation between the level of protein expression and CTL response after immunization of C57BL/6 mice / Steinberg, Thorsten ; Öhlschläger, Peter ; Sehr, Peter ; Osen, Wolfram ; Gissmann, Lutz (2005)
Peter Öhlschläger ; Thorsten Steinberg ; Peter Sehr ; Wolfram Osen
The combination of TLR-9 adjuvantation and electroporation-mediated delivery enhances in vivo antitumor responses after vaccination with HPV-16 E7 encoding DNA (2011)
Peter Öhlschläger ; Elmar Spies ; Gerardo Alvarez ; Michael Quetting ; Marcus Groettrup
Enhancement of immunogenicity of a therapeutic cervical cancer DNA-based vaccine by co-application of sequence-optimized genetic adjuvants (2009)
Peter Öhlschläger ; Michael Quetting ; Gerardo Alvarez ; Matthias Dürst ; Lutz Gissmann ; Andreas M. Kaufmann
An improved rearranged Human Papillomavirus Type 16 E7 DNA vaccine candidate (HPV-16 E7SH) induces an E7 wildtype-specific T cell response / Öhlschläger, Peter ; Pes, Michaela ; Osen, Wolfram ; Dürst, Matthias ; Schneider, Achim ; Gissmann, Lutz ; Kaufman (2006)
Peter Öhlschläger ; Michaela Pes ; Wolfram Osen ; Matthias Dürst
A DNA vaccine based on a shuffled E7 oncogene of the human papillomavirus type 16 (HPV 16) induces E7-specific cytotoxic T cells but lacks transforming activity / Osen, Wolfram ; Peiler, Tanja ; Öhlschläger, Peter ; Caldeira, Sandra ; Faath, Stefan ; Mich (2001)
Peter Öhlschläger ; Wolfram Osen ; Tanja Peiler ; Sandra Caldeira
Human papillomavirus type 16 L1 capsomeres induce L1-specific cytotoxic T lymphocytes and tumor regression in C57BL/6 mice / Öhlschläger, Peter ; Osen, Wolfram ; Dell, Kerstin ; Faath, Stefan ; Garcea Robert L: ; Jochmus, Ingrid ; Müller, Martin, Pawlita, (2003)
Peter Öhlschläger ; Wolfram Osen ; Kerstin Dell ; Stefan Faath
T cell response to human papillomavirus 16 E7 in mice: comparison of Cr release assay, intracellular IFN-gamma production, ELISPOT and tetramer staining / Michel, Nico ; Öhlschläger, Peter ; Osen, Wolfram ; Freyschmidt, Eva-Jasmin ; Gutöhrlein, Heidrun ; (2002)
Peter Öhlschläger ; Nico Michel ; Wolfram Osen ; Eva-Jasmin Freyschmidt
Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth / Corvinus, Florian, Moriggl, Richard ; Tsareva, Svetlana A. ; Wagner, Stefan ; Pfitzner, Edith B. ; Baus, Daniela ; Kaufmann, Roland : Huber, Luka (2005)
Peter Öhlschläger ; Florian M. Corvinus ; Carina Orth ; Richard Moriggl
Elektrodenlose quecksilberfreie Niederdrucklampen betrieben mit Mikrowellen (2014)
Celal Mohan Ögun ; Rainer Kling ; Holger Heuermann ; Ulrich Gräser ; Christoph Schopp
An Integration Challenge to Bridge the Gap Among Industry-Inspired RoboCup Leagues (2017)
Sebastian Zug ; Tim Niemueller ; Nico Hochgeschwender ; Kai Seidensticker ; Martin Seidel ; Tim Friedrich ; Tobias Neumann ; Ulrich Karras ; Gerhard K. Kraetzschmar ; Alexander Ferrein
Assessment of the lightning transient coupling to control cables interconnecting structures in large industrial facilities and power plants (2000)
Wolfgang J. Zischank ; Alexander Kern ; Ralf Frentzel ; Fridolin Heidler ; M. Seevers
Large industrial facilities and power plants often require a huge number fo information and control cables between the differnet structures. These I&C-cables can be routed in reinforced concrete cable ducts or in isolated buried cable runs. KTA 2206 is the German lightning protection standard for nuclear power plants. During the last several years considerable effort has been made to revise this standard. Despite the well established principles and design guidelines for the construction of the lightning protection system, this standard puts special emphasis on the coupling of transient overvoltages to I&C-cables.
Magnetic Fields and Induced Voltages inside LPZ 1 Measured at a 1:6 Scale Model Building (2004)
Wolfgang J. Zischank ; Fridolin Heidler ; J. Wiesinger ; K. Stimper ; Alexander Kern ; M. Seevers
For the application of the concept of Lightning Protection Zones (LPZ), the knowledge of the magnetic fields and induced voltages inside a structure is necessary. Laboratory experiments have been conducted at a downscaled model of a building (scale factor 1:6) to determine these electromagnetic quantities in case of a direct strike to the structure. The model (3 m x 2 m x 2 m) represented a small industrial building using the reinforcement of the concrete as electromagnetic shield. The magnetic fields and magnetic field derivatives were measured at several location inside the scaled model. Further, the voltages induced on three typical cable routes inside the model was determined. The influence of the lightning current waveshape, point-of-strike, bonding of the cable routes, and bridging of an expansion joint in the middle of the building on these quantities was studied.
Laboratory simulation of direct lightning strokes to a modeled building : measurement of magnetic fields and included voltages (2004)
Wolfgang J. Zischank ; Fridolin Heidler ; J. Wiesinger ; I. Metwally ; Alexander Kern ; M. Seevers
Laboratory simulation of direct lightning strokes to a modelled building - measurement of magnetic fields and induced voltages (2002)
Wolfgang J. Zischank ; Fridolin Heidler ; Alexander Kern ; I. A. Metwally ; J. Wiesinger ; M. Seevers
In IEC 61312-2 equations for the assessment of the magnetic fields inside structures due to a direct lightning strike are given. These equations are based on computer simulations for shields consisting of a single-layer steel grid of a given mesh width. Real constructions, however, contain at least two layers of reinforcement steel grids. The objective of this study was to experimentally determine the additional shielding effectiveness of a second reinforcement layer compared to a single-layer grid. To this end, simulated structures were set up in the high current laboratory. The structures consisted of cubic cages of 2 m side length with one or with two reinforcement grids, respectively. The structures were exposed to direct lightning currents representing the variety of anticipated lightning current waveforms. The magnetic fields and their derivatives at several positions inside the structure as well as the voltage between “floor” and “roof” in the center were determined for different current injection points. From these data the improvement of the shielding caused by a second reinforcement layer is derived.
Ökobilanzielle Aspekte technologischer Entwicklungen des Solarturmkraftwerks (2011)
Christoph Ziolko ; Barbara Fricke ; Anette Anthrakidis ; Bernhard Hoffschmidt ; Marius Dillig ; Frank Giese ; Peter Schwarzbözl
AlSol - the open volumetric receiver technology moves to Africa (2010)
C. Ziolko ; M. Schmitz ; Johannes Sattler ; Ahmed Khedim ; Bernhard Hoffschmidt
Recognition of subjects with mild cognitive impairment (MCI) by the use of retinal arterial vessels. (2019)
Jonas Zingsheim ; Timo Grimmer ; Marion Ortner ; Christoph Schmaderer ; Christine Hauser ; Konstantin Kotliar
[Kapitel 7] : Externes Rechnungswesen (2007)
Doris Zimmermann
Doppelfassaden - vom Experimentalmodell zum Massanzug (2004)
Claudia Ziller ; Bernd Döring
Influence of the external dynamic wind pressure on the ventilation of double facades (2003)
Claudia Ziller ; Bernd Döring
Fumarate regulation of gene expression in Escherichia coli by the DcuSR (dcuSR genes) two-component regulatory system (1998)
Evelyn Zientz ; Johannes Bongaerts ; Gottfried Unden
IME-DV Projekt: M-FIRBe, Multi-Modality Functional Imaging for Brain Research (1997)
Karl Ziemons ; H. Kleines ; I. Erken ; J. Knoben ; K. Zwoll
Iterative image reconstruction with weighted pixel contribution to projection element (1990)
Karl Ziemons ; H. Herzog ; L. E. Feinendegen
Iterative image reconstruction with weighted pixel contribution to projection elements (1992)
Karl Ziemons ; H. Herzog ; P. Bosetti ; L. E. Feinendegen
Validation of GEANT3 simulation studies with a dual-head PMT ClearPET™ prototype (2004)
Karl Ziemons ; U. Heinrichs ; M. Streun ; U. Pietrzyk
The ClearPET™ project is proposed by working groups of the Crystal Clear Collaboration (CCC) to develop a 2nd generation high performance small animal positron emission tomograph (PET). High sensitivity and high spatial resolution is foreseen for the ClearPET™ camera by using a phoswich arrangement combining mixed lutetium yttrium aluminum perovskite (LuYAP:Ce) and lutetium oxyorthosilicate (LSO) scintillating crystals. Design optimizations for the first photomultiplier tube (PMT) based ClearPET camera are done with a Monte-Carlo simulation package implemented on GEANT3 (CERN, Geneva, Switzerland). A dual-head prototype has been built to test the frontend electronics and was used to validate the implementation of the GEANT3 simulation tool. Multiple simulations were performed following the experimental protocols to measure the intrinsic resolution and the sensitivity profile in axial and radial direction. Including a mean energy resolution of about 27.0% the simulated intrinsic resolution is about (1.41±0.11)mm compared to the measured of (1.48±0.06)mm. The simulated sensitivity profiles show a mean square deviation of 12.6% in axial direction and 3.6% in radial direction. Satisfactorily these results are representative for all designs and confirm the scanner geometry.
Beyond ClearPET: Next Aims (2008)
Karl Ziemons ; P. Bruyndonckx ; J. M. Perez ; U. Pietrzyk ; P. Rato ; S. Tavernier
The CRYSTAL CLEAR collaboration, in short CCC, is a consortium of 12 academic institutions, mainly from Europe, joining efforts in the area of developing instrumentation for nuclear medicine and medical imaging. In the framework of the CCC a high performance small animal PET system, called ClearPET, was developed by using new technologies in electronics and crystals in a phoswich arrangement combining two types of lutetium- based scintillator materials: LSO:Ce and LuYAP:Ce. Our next aim will be the development of hybrid image systems. Hybrid MR-PET imaging has many unique advantages for brain research. This has sparked a new research line within CCC for the development of novel MR-PET compatible technologies. MRI is not as sensitive as PET but PET has poorer spatial resolution than MRI. Two major advantages of PET are sensitivity and its ability to acquire metabolic information. To assess these innovations, the development of a 9.4T hybrid animal MR-PET scanner is proposed based on an existing 9.4T MR scanner that will be adapted to enable simultaneous acquisition of MR and PET data using cutting- edge technology for both MR and PET.
Strangeness production in deep inelastic muon-nucleon scattering (1988)
Karl Ziemons ; G. Berghoff ; D. Lanske ; K. Schultze
The ClearPET™ project: Development of a 2nd generation high-performance small animal PET scanner (2005)
Karl Ziemons ; E. Auffray ; R. Barbier ; G. Brandenburg ; P. Bruyndonckx
Second generation high-performance PET scanners, called ClearPET™1, have been developed by working groups of the Crystal Clear Collaboration (CCC). High sensitivity and high spatial resolution for the ClearPET camera is achieved by using a phoswich arrangement combining two different types of lutetium-based scintillator materials: LSO from CTI and LuYAP:Ce from the CCC (ISTC project). In a first ClearPET prototype, phoswich arrangements of 8×8 crystals of 2×2×10 mm3 are coupled to multi-channel photomultiplier tubes (Hamamatsu R7600). A unit of four PMTs arranged in-line represents one of 20 sectors of the ring design. The opening diameter of the ring is 120 mm, the axial detector length is 110 mm.The PMT pulses are digitized by free-running ADCs and digital data processing determines the gamma energy, the phoswich layer and even the exact pulse starting time, which is subsequently used for coincidence detection. The gantry allows rotation of the detector modules around the field of view. Preliminary data shows a correct identification of the crystal layer about (98±1)%. Typically the energy resolution is (23.3±0.5)% for the luyap layer and (15.4±0.4)% for the lso layer. early studies showed the timing resolution of 2 ns FWHM and 4.8 ns FWTM. the intrinsic spatial resolution ranges from 1.37 mm to 1.61 mm full-width of half-maximum (FWHM) with a mean of 1.48 mm FWHM. further improvements in image and energy resolution are expected when the system geometry is fully modeled.
The ClearPET TM LSO/LuYAP phoswich scanner: a high performance small animal PET system (2004)
Karl Ziemons ; E. Auffray ; R. Barbier ; G. Brandenburg
A 2nd generation high performance small animal PET scanner, called ClearPET™, has been designed and a first prototype is built by working groups of the Crystal Clear Collaboration (CCC). In order to achieve high sensitivity and maintain good uniform spatial resolution over the field of view in high resolution PET systems, it is necessary to extract the depth of interaction (DOI) information and correct for spatial degradation. The design of the first ClearPET™ Demonstrator based on the use of the multi-anode photomultiplier tube (Hamamatsu R7600-M64) and a LSO/LuYAP phoswich matrix. The two crystal layers of 8*8 crystals (2*2*10 mm3) are stacked on each other and mounted without light guide as one to one on the PMT. A unit of four PMTs arranged in-line represents one of 20 sectors of the ring design. The opening diameter of the crystal ring is 137 mm, the axial detector length is 110 mm. The PMT pulses are digitized by free-running ADCs and digital data processing determines the gamma energy, the phoswich layer and even the pulse arrival time. Single gamma interactions are recorded and coincidences are found by software. The gantry allows rotation of the detector modules around the field of view. The measurements have been done using the first LSO/LuYAP detector cassettes.
The ClearPET neuro scanner: a dedicated LSO/LuYAP phoswich small animal PET scanner (2004)
Karl Ziemons ; R. Achten ; E. Auffray ; Mattea Müller-Veggian
A measurement of the spin asymmetry of the structure function g1 in deep inelastic muon-proton scattering (1988)
Karl Ziemons
The spin asymmetry in deep inelastic scattering of longitudinally polarised muons by longitudinally polarised protons has been measured over a large x range (0.01<x<0.7). The spin-dependent structure function g1(x) for the proton has been determined and its integral over x found to be 0.114±0.012±0.026, in disagreement with the Ellis-Jaffe sum rule. Assuming the validity of the Bjorken sum rule, this result implies a significant negative value for the integral of g1 for the neutron. These values for the integrals of g1 lead to the conclusion that the total quark spin constitutes a rather small fraction of the spin of the nucleon.
Jet production and fragmentation properties in deep inelastic muon scattering (1987)
Karl Ziemons
An investigation of the spin structure of the proton in deep inelastic scattering of polarised muons and polarised protons (1989)
Karl Ziemons
The spin asymmetry in deep inelastic scattering of longitudinally polarised muons by longitudinally polarised protons has been measured in the range 0.01<×<0.7. The spin dependent structure function g1(x) for the proton has been determined and, combining the data with earlier SLAC measurements, its integral over x found to be 0.126±0.010(stat.)±0.015(syst.), in disagreement with the Ellis-Jaffe sum rule. Assuming the validity of the Biorken sum rule, this result implies a significant negative value for the integral of g1 for the neutron. These integrals lead to the conclusion, in the naïve quark parton model, that the total quark spin constitutes a rather small fraction of the spin of the nucleon. Results are also presented on the asymmetries in inclusive hadron production which are consistent with the above picture.
Comparison of forward hadrons produced in muon interactions on nuclear targets and deuterium (1991)
Karl Ziemons
Differential multiplicities of forward produced hadrons in deep inelastic muon scattering on nuclear targets have been compared with those from deuterium. The ratios are observed to increase towards unity as the virtual photon energy increases with no significant dependence on the other muon kinematic variables. The hadron transverse momentum distribution is observed to be broadened in nuclear targets. The dependence on the remaining hadron variables is investigated and the results are discussed in the framework of intranuclear interaction models and in the context of the EMC effect.
Muoproduction of J/ψ and the gluon distribution of the nucleon (1992)
Karl Ziemons
Measurements are presented of the inclusive distributions of the J/Ψ meson produced by muons of energy 200 GeV from an ammonia target. The gluon distribution of the nucleon has been derived from the data in the range 0.04<x<0.36 using a technique based on the colour singlet model. An arbitrary normalisation factor is required to obtain a reasonable integral of the gluon distribution. Some comments are made on the use of J/Ψ productionby virtual photons to extract the gluon distribution at HERA.
A measurement of the ratio of the nucleon structure function in copper and deuterium (1993)
Karl Ziemons
Results are presented on the ratios of the nucleon structure function in copper to deuterium from two separate experiments. The data confirm that the nucleon structure function,F 2, is different for bound nucleons than for the quasi-free ones in the deuteron. The redistribution in the fraction of the nucleon's momentum carried by quarks is investigated and it is found that the data are compatible with no integral loss of quark momenta due to nuclear effects.
Numerical simulation of energy consumption of artificial ground freezing applications subject to water seepage (2013)
M. Ziegler ; R. Schüller ; Darius Mottaghy
Machbarkeitsstudie zur Verarbeitung von nicht rostendem Stahl 1.4404 unter Verwendung einer Diodenlaser-basierten LPBF-Maschine mit kartesischem Achssystem (2018)
Dawid Ziebura ; Sebastian Bremen ; Johannes Henrich Schleifenbaum ; Andreas Gebhardt
Designing of Heterogeneous Nanobiocomposites for Biotechnology (2013)
А. Zhubanova ; Z.A. Mansurov ; Ilya Digel ; I.S. Saviskaya ; N.Sh. Akimbekov
Use of Advanced Nanomaterials for Bioremediation of Contaminated Ecosystems (2020)
Azhar A. Zhubanova ; Zulkhair A. Mansurov ; Ilya Digel
The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology (2007)
Azhar A. Zhubanova ; Ilya Digel ; H. Nojima ; Gerhard Artmann
The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells.
Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials (2010)
Azhar A. Zhubanova ; S. K. Aknazarov ; Zulkhair Mansurov ; Ilya Digel ; A. A. Kozhalakova ; Nuraly Shardarbekovich Akimbekov ; Carlos O'Heras ; S. Tazhibayeva ; Gerhard Artmann ; Aysegül Temiz Artmann
Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment.
Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4–Humanized Mouse Studies With PBPK Modeling (2016)
Jin Zhang ; Tycho Heimbach ; Nico Scheer ; Avantika Barve ; Wenkui Li ; Wen Lin ; Handan He
On the estimation of free-surface turbulence using ultrasonic sensors (2018)
G. Zhang ; Daniel Valero ; Daniel Bung ; H. Chanson
Structural transition temperature of hemoglobins correlates with species’ body temperature (2007)
Kay Zerlin ; Nicole Kasischke ; Ilya Digel ; Christina Maggakis-Kelemen ; Aysegül Temiz Artmann ; Dariusz Porst ; Peter Kayser ; Peter Linder ; Gerhard Artmann
Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions (2007)
Kay Zerlin ; Ilya Digel ; Andreas M. Stadler ; Georg Büldt ; Guiseppe Zaccai ; Gerhard Artmann
On the spectrometric performance limit of radiation detectors based on semi-insulating GaAs (2004)
B. Zatko ; F. Dubecký ; P. Bohacek ; E. Gombia ; P. Frigeri ; R. Mosca ; S. Franchi ; J. Huarn ; V. Nescas ; M. Sekacova ; Arnold Förster ; P. Kordos
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