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TOP-Energy : softwaregestützte Analyse und Optimierung industrieller Energieversorgungssysteme
(2004)
The ClearPET project
(2004)
The Crystal Clear Collaboration has designed and is building a high-resolution small animal PET scanner. The design is based on the use of the Hamamatsu R7600-M64 multi-anode photomultiplier tube and a LSO/LuYAP phoswich matrix with one to one coupling between the crystals and the photo-detector. The complete system will have 80 PM tubes in four rings with an inner diameter of 137 mm and an axial field of view of 110 mm. The PM pulses are digitized by free-running ADCs and digital data processing determines the gamma energy, the phoswich layer and even the pulse arrival time. Single gamma interactions are recorded and coincidences are found by software. The gantry allows rotation of the detector modules around the field of view. Simulations, and measurements a 2×4 module test set-up predict a spatial resolution of 1.5 mm in the centre of the field of view and a sensitivity of 5.9% for a point source in the centre of the field of view.
Mit der App »atmosphere« soll die Veranstaltungsbranche in die digitale Welt eingeführt werden. Insbesondere nach der COVID–19 Pandemie bedarf es einer Erneuerung in dem Sektor für Liveunterhaltung. Die Auswirkungen der Krise auf diesen Wirtschaftszweig waren enorm und auch das Publikum litt unter der Situation. Die Mission von »atmosphere« besteht darin, den Zugang zu Veranstaltungen, Konzerten, Stand–Up–Auftritten und Festivals zu vereinfachen. Hierbei werden die Bereiche der Planung und der Buchung komplett in dem Service der App abgedeckt und die digitale Teilnahme an einem Event ermöglicht. Dies bietet neue Möglichkeiten für die Zukunft und dient als Alternative für Krisen. Insgesamt soll der Service den Zugang vereinfachen, die aufwendigen Planungsschritte reduzieren und die Knackpunkte in der Nutzererfahrung digitalisieren.
The esophageal Doppler monitor (EDM) is a minimally-invasive hemodynamic device which evaluates both cardiac output (CO), and fluid status, by estimating stroke volume (SV) and calculating heart rate (HR). The measurement of these parameters is based upon a continuous and accurate approximation of distal thoracic aortic blood flow. Furthermore, the peak velocity (PV) and mean acceleration (MA), of aortic blood flow at this anatomic location, are also determined by the EDM. The purpose of this preliminary report is to examine additional clinical hemodynamic calculations of: compliance (C), kinetic energy (KE), force (F), and afterload (TSVRi). These data were derived using both velocity-based measurements, provided by the EDM, as well as other contemporaneous physiologic parameters. Data were obtained from anesthetized patients undergoing surgery or who were in a critical care unit. A graphical inspection of these measurements is presented and discussed with respect to each patient’s clinical situation. When normalized to each of their initial values, F and KE both consistently demonstrated more discriminative power than either PV or MA. The EDM offers additional applications for hemodynamic monitoring. Further research regarding the accuracy, utility, and limitations of these parameters is therefore indicated.
GummiQs Reisen
(2022)
Dieser Film ist ein Trailer zur Mini-Serie GummiQs Reisen, welche von den fantastischen Abenteuern der Entdeckerinnen GummiQ und Kreska Krähenschreck erzählt.
Gemeinsam erkunden sie auf ihrem Kahn, der Kaleidoskop?, eine lebensfrohe Ozeanwelt, die mit winzigen, einzigartigen Inseln gespickt ist. Im Gegensatz zur jungen GummiQ, die zum ersten Mal verreist, ist Kreska schon eine erfahrene Seefahrerin und wird GummiQs Kapitänin und Mentorin. Sie leitet GummiQ nicht nur durch das Meer, sondern auch durch philosophische Gefilde. Denn jede Insel birgt ein eigenes soziales Dilemma, welches das ungewöhnliche Paar immer wieder dazu herausfordert, die Welt zu hinterfragen, von der sie glaubten, sie zu kennen.
Gesprochen von Marianne Graffam. Musik von Eric Michels.
Geschrieben und produziert von Miriam De Stefano und Mara Asmuth.
Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative “CellDrum technology” was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology.
The invention pertains to a CellDrum electrode arrangement for measuring mechanical stress, comprising a mechanical holder (1 ) and a non-conductive membrane (4), whereby the membrane (4) is at least partially fixed at its circumference to the mechanical holder (1), keeping it in place when the membrane (4) may bend due to forces acting on the membrane (4), the mechanical holder (1) and the membrane (4) forming a container, whereby the membrane (1) within the container comprises an cell- membrane compound layer or biological material (3) adhered to the deformable membrane 4 which in response to stimulation by an agent may exert mechanical stress to the membrane (4) such that the membrane bending stage changes whereby the container may be filled with an electrolyte, whereby an electric contact (2) is arranged allowing to contact said electrolyte when filled into to the container, whereby within a predefined geometry to the fixing of the membrane (4) an electrode (7) is arranged, whereby the electrode (7) is electrically insulated with respect to the electric contact (2) as well as said electrolyte, whereby mechanical stress due to an agent may be measured as a change in capacitance.
Tests with palm tree leaves have just started yet and scan data are in the process to be analyzed. The final goal of future project for palm tree gender and species recognition will be to develop optical scanning technology to be applied to date palm tree leaves for in–situ screening purposes. Depending on the software used and the particular requirements of the users the technology potentially shall be able to identify palm tree diseases, palm tree gender, and species of young date palm trees by scanning leaves.