Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process
- A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.
| Author: | Shoko Takenaga, Benno Schneider, E. Erbay, Manfred Biselli, Thomas Schnitzler, Michael Josef SchöningORCiD, Torsten WagnerORCiD |
|---|---|
| DOI: | https://doi.org/10.1002/pssa.201532053 |
| ISSN: | 1862-6319 |
| Parent Title (English): | Physica status solidi (a) |
| Publisher: | Wiley |
| Place of publication: | Weinheim |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2015 |
| Date of first Publication: | 2015/05/26 |
| Date of the Publication (Server): | 2015/07/24 |
| Volume: | 212 |
| Issue: | 6 |
| First Page: | 1347 |
| Last Page: | 1352 |
| Link: | https://doi.org/10.1002/pssa.201532053 |
| Zugriffsart: | campus |
| Institutes: | FH Aachen / Fachbereich Chemie und Biotechnologie |
| FH Aachen / Fachbereich Medizintechnik und Technomathematik | |
| FH Aachen / INB - Institut für Nano- und Biotechnologien | |
| collections: | Verlag / Wiley |
