Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process
- A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.
| Verfasserangaben: | Shoko Takenaga, Benno Schneider, E. Erbay, Manfred Biselli, Thomas Schnitzler, Michael Josef SchöningORCiD, Torsten WagnerORCiD |
|---|---|
| DOI: | https://doi.org/10.1002/pssa.201532053 |
| ISSN: | 1862-6319 |
| Titel des übergeordneten Werkes (Englisch): | Physica status solidi (a) |
| Verlag: | Wiley |
| Verlagsort: | Weinheim |
| Dokumentart: | Wissenschaftlicher Artikel |
| Sprache: | Englisch |
| Erscheinungsjahr: | 2015 |
| Datum der Erstveröffentlichung: | 26.05.2015 |
| Datum der Publikation (Server): | 24.07.2015 |
| Jahrgang: | 212 |
| Ausgabe / Heft: | 6 |
| Erste Seite: | 1347 |
| Letzte Seite: | 1352 |
| Link: | https://doi.org/10.1002/pssa.201532053 |
| Zugriffsart: | campus |
| Fachbereiche und Einrichtungen: | FH Aachen / Fachbereich Chemie und Biotechnologie |
| FH Aachen / Fachbereich Medizintechnik und Technomathematik | |
| FH Aachen / INB - Institut für Nano- und Biotechnologien | |
| collections: | Verlag / Wiley |
