Refine
Year of publication
- 2010 (328) (remove)
Document Type
- Article (176)
- Conference Proceeding (73)
- Book (38)
- Part of a Book (20)
- Patent (7)
- Report (5)
- Other (2)
- Part of Periodical (2)
- Contribution to a Periodical (1)
- Doctoral Thesis (1)
- Master's Thesis (1)
- Talk (1)
- Working Paper (1)
Language
- English (179)
- German (147)
- Italien (1)
- Multiple languages (1)
Keywords
- Aachen / Fachhochschule Aachen (3)
- Aachen University of Applied Sciences (3)
- FH Aachen (2)
- Geschichte (2)
- avalanche (2)
- Cardiovascular MRI (1)
- Commercial Vehicle (1)
- Common Rail Injection System (1)
- Dekontamination (1)
- Diesel Engine (1)
- Endothelzelle (1)
- Erythrozyt (1)
- European Transient Cycle (1)
- Fachhochschule Aachen (1)
- Forschungsbericht (1)
- Graduiertentagung (1)
- Hämoglobin (1)
- Illustration (1)
- Kohlenstofffaser (1)
- Körpertemperatur (1)
Institute
- Fachbereich Medizintechnik und Technomathematik (72)
- Fachbereich Wirtschaftswissenschaften (41)
- IfB - Institut für Bioengineering (40)
- Fachbereich Elektrotechnik und Informationstechnik (35)
- Fachbereich Energietechnik (31)
- Fachbereich Maschinenbau und Mechatronik (31)
- Fachbereich Chemie und Biotechnologie (26)
- Fachbereich Bauingenieurwesen (24)
- Fachbereich Luft- und Raumfahrttechnik (24)
- INB - Institut für Nano- und Biotechnologien (24)
- Fachbereich Architektur (14)
- Solar-Institut Jülich (13)
- Fachbereich Gestaltung (5)
- Sonstiges (5)
- ECSM European Center for Sustainable Mobility (4)
- FH Aachen (4)
- ZHQ - Bereich Hochschuldidaktik und Evaluation (2)
- IBB - Institut für Baustoffe und Baukonstruktionen (1)
Epilepsy
(2010)
Various models have been proposed for the prediction of the necessary support pressure at the face of a shallow tunnel. To assess their quality, the collapse of a tunnel face was modelled with small-scale model tests at single gravity. The development of the failure mechanism and the support force at the face in dry sand were investigated. The observed displacement patterns show a negligible influence of overburden on the extent and evolution of the failure zone. The latter is significantly influenced, though, by the initial density of the sand: in dense sand a chimney-wedge-type collapse mechanism developed, which propagated towards the soil surface. Initially, loose sand did not show any discrete collapse mechanism. The necessary support force was neither influenced by the overburden nor the initial density. A comparison with quantitative predictions by several theoretical models showed that the measured necessary support pressure is overestimated by most of the models. Those by Vermeer/Ruse and Léca/Dormieux showed the best agreement to the measurements.
Purpose
To assess potential cognitive deficits under the influence of static magnetic fields at various field strengths some studies already exist. These studies were not focused on attention as the most vulnerable cognitive function. Additionally, mostly no magnetic resonance imaging (MRI) sequences were performed.
Materials and Methods
In all, 25 right-handed men were enrolled in this study. All subjects underwent one MRI examination of 63 minutes at 1.5 T and one at 7 T within an interval of 10 to 30 days. The order of the examinations was randomized. Subjects were referred to six standardized neuropsychological tests strictly focused on attention immediately before and after each MRI examination. Differences in neuropsychological variables between the timepoints before and after each MRI examination were assessed and P-values were calculated
Results
Only six subtests revealed significant differences between pre- and post-MRI. In these tests the subjects achieved better results in post-MRI testing than in pre-MRI testing (P = 0.013–0.032). The other tests revealed no significant results.
Conclusion
The improvement in post-MRI testing is only explicable as a result of learning effects. MRI examinations, even in ultrahigh-field scanners, do not seem to have any persisting influence on the attention networks of human cognition immediately after exposure.
Fast response of Scots pine to improved water availability reflected in tree-ring width and δ13C
(2010)
Drought-induced forest decline, like the Scots pine mortality in inner-Alpine valleys, will gain in importance as the frequency and severity of drought events are expected to increase. To understand how chronic drought affects tree growth and tree-ring δ13C values, we studied mature Scots pine in an irrigation experiment in an inner-Alpine valley. Tree growth and isotope analyses were carried out at the annual and seasonal scale. At the seasonal scale, maximum δ13C values were measured after the hottest and driest period of the year, and were associated with decreasing growth rates. Inter-annual δ13C values in early- and latewood showed a strong correlation with annual climatic conditions and an immediate decrease as a response to irrigation. This indicates a tight coupling between wood formation and the freshly produced assimilates for trees exposed to chronic drought. This rapid appearance of the isotopic signal is a strong indication for an immediate and direct transfer of newly synthesized assimilates for biomass production. The fast appearance and the distinct isotopic signal suggest a low availability of old stored carbohydrates. If this was a sign for C-storage depletion, an increasing mortality could be expected when stressors increase the need for carbohydrate for defence, repair or regeneration.
formine 2010 ... ein Haus ... : Workshop ; Fachbereich Architektur / Tünnemann, Thomas [Red.]
(2010)
Forschungsbericht 2010
(2010)
Forschungsbericht / Themenheft : Energie, Mobilität, Luft- und Raumfahrt. 72 S. : Ill., graph. Darst. gedruckte Ausgabe unter der Signatur 91 AKN 100-2010 Inhaltsverzeichnis: 4 Grußworte Prorektorin Prof. Dr. rer. nat. Christiane Vaeßen 6 Highlightprojekte 10 Solar-Institut-Jülich 11 Aquasol und CuveWaters 13 PaRiKo 14 Science College Overbach 15 Summer School Renewable Energy 16 Solarturm Jülich 18 Hochtemperatur-Wanderbett-Wärmeübertrager 20 Stromversorgung mit einem hohen Anteil erneuerbarer Energieerzeuger 21 Standards für solare Prozesswäre 22 Solarturmtechnik (viCERP) 24 Novum-Institut 25 MAK-Energie 26 Exbrut 27 Biogasversuchsanlage 28 MiProBa 30 Elektrotechnik 30 Ultrakompakte Leuchtstofflampe 32 ITP Mobilität 34 Elektromobilität 34 E_bike 37 Konzept-Elektrofahrzeug 4e4 40 Elektromobilitätskonzepte 43 Mobilität und Verkehr 43 Mobiliätskonzept für FH Aachen 44 Luft- und Raumfahrt, Automotive 44 Sonnensegel 46 COMPASS 48 Antriebe für Werkzeugmaschinen und Fahrzeuge 50 SAAE 52 Wasserstoff-Gasturbine 53 HyDI 54 Bioethanol als Flugbenzin 56 Zertifizierung von Luftfahrtantrieben 58 Hydrostatischer Probellerantrieb 59 Hybridantrieb und Flugzeug 61 Mix-SCR 62 Abgasnachbehandlung 3D-Keramik 63 VisMut 64 WING 68 Silent Structure 70 Entwicklungspotenzial bei variablen Kfz-Ölpumpen 72 Kunststoff-Rotationsmesser
Die Entwicklungen der Rechtsinformatik und des Informationsrechts zeigen, dass diese Disziplinen aktuell vor der Herausforderung stehen, eine interdisziplinäre Zusammenarbeit zwischen ihnen und anderen Disziplinen zu etablieren. Unterschiedliche Publikationskulturen erschweren die Erreichung dieses Ziels. Forschungsportale stellen themenspezifische, internetbasierte Verzeichnisse dar, die bereits vorhandene Informationen strukturiert zugänglich machen. Sie können die Beziehungen zwischen den Disziplinen fördern, indem sie bereits erzielte Arbeitsergebnisse disziplinenübergreifend bekannt machen und dadurch dazu beitragen, Synergiepotenziale und mögliche Kooperationspartner zu identifizieren.
We consider recent reports on small-world topologies of interaction networks derived from the dynamics of spatially extended systems that are investigated in diverse scientific fields such as neurosciences, geophysics, or meteorology. With numerical simulations that mimic typical experimental situations, we have identified an important constraint when characterizing such networks: indications of a small-world topology can be expected solely due to the spatial sampling of the system along with the commonly used time series analysis based approaches to network characterization.
Gas sensor investigation based on a catalytically activated thin-film thermopile for H2O2 detection
(2010)
Grassilage stellt einen nachwachsenden Rohstoff mit großem Potenzial dar. Neben Cellulose und Hemicellulose enthält sie auch organische Säuren, insbesondere Milchsäure. In einem Bioraffinerie-Projekt wird die Milchsäure aus der Silage isoliert und mit gentechnisch optimierten Stämmen zu L-Lysin weiterverarbeitet. Die Lignocellulose wird hydrolysiert und zu Ethanol fermentiert. Ein besonderes Augenmerk liegt auf der Integration der unterschiedlichen Prozesse sowie der einzelnen Prozessschritte zu einem Gesamtprozess, der sämtliche Inhaltsstoffe der Silage verwertet.
Die Anforderungen an das energiesparende Bauen sind mit der Einführung der Energieeinsparverordnung (EnEV) 2009 auch im Industrie- und Gewerbebau deutlich verschärft worden. Einen wesentlichen Beitrag zur Energieeinsparung liefert die Minimierung des Transmissionswärmetransfers. Analysiert man Gebäudehüllen in Metallleichtbauweise stellt man fest, dass eine Erhöhung der Wärmedämmstärke allein noch nicht zielführend ist, zusätzlich sind Wärmebrückeneffekte zu berücksichtigen und deren Einflüsse auf die Wärmetransmission zu reduzieren. Neben der Bedeutung für die Energieeinsparung ist eine wärmetechnisch optimierte Detailausbildung auch erforderlich, um einen ausreichenden Feuchteschutz (Vermeidung von Tauwasser und Schimmelpilz) zu realisieren und so Schäden zu vermeiden. Ein wichtiges Hilfsmittel stellt hierzu der vom Industrieverband für Bausysteme im Metallleichtbau (IFBS) herausgegebene Wärmebrückenatlas der Metall-Sandwichbauweise dar.
Hamburg 2010 : Hafencity, Jungfernstieg, IBA 2013, Chilehaus, Speicherstadt, BRT Architekten.
(2010)
Helle Fensterprofilmaterialien : Alterungsverhalten auf Basis von peroxidisch vernetztem EPDM
(2010)
Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to human health is unclear. The xenoreceptors, constitutive androstane receptors (CARs), and pregnane X receptor (PXR) play key roles in these processes. Novel “humanized” and knockout models for both receptors were developed to investigate potential species differences in hepatomegaly. The effects of PB (80 mg/kg/4 days) and chlordane (10 mg/kg/4 days) were investigated in double humanized PXR and CAR (huPXR/huCAR), double knockout PXR and CAR (PXRKO/CARKO), and wild-type (WT) C57BL/6J mice. In WT mice, both compounds caused increased liver weight, hepatocellular hypertrophy, and cell proliferation. Both compounds caused alterations to a number of cell cycle genes consistent with induction of cell proliferation in WT mice. However, these gene expression changes did not occur in PXRKO/CARKO or huPXR/huCAR mice. Liver hypertrophy without hyperplasia was demonstrated in the huPXR/huCAR animals in response to both compounds. Induction of the CAR and PXR target genes, Cyp2b10 and Cyp3a11, was observed in both WT and huPXR/huCAR mouse lines following treatment with PB or chlordane. In the PXRKO/CARKO mice, neither liver growth nor induction of Cyp2b10 and Cyp3a11 was seen following PB or chlordane treatment, indicating that these effects are CAR/PXR dependent. These data suggest that the human receptors are able to support the chemically induced hypertrophic responses but not the hyperplastic (cell proliferation) responses. At this time, we cannot be certain that hCAR and hPXR when expressed in the mouse can function exactly as the genes do when they are expressed in human cells. However, all parameters investigated to date suggest that much of their functionality is maintained.
Hybrid control for autonomous systems — Integrating learning, deliberation and reactive control
(2010)
Dexamethasone (DEX) is a potent and widely used anti-inflammatory and immunosuppressant glucocorticoid. It can bind and activate the pregnane X receptor (PXR), which plays a critical role as xenobiotic sensor in mammals to induce the expression of many enzymes, including cytochromes P450 in the CYP3A family. This induction results in its own metabolism. We have used a series of transgenic mouse lines, including a novel, improved humanized PXR line, to compare the induction profile of PXR-regulated drug-metabolizing enzymes after DEX administration, as well as looking at hepatic responses to rifampicin (RIF). The new humanized PXR model has uncovered further intriguing differences between the human and mouse receptors in that RIF only induced Cyp2b10 in the new humanized model. DEX was found to be a much more potent inducer of Cyp3a proteins in wild-type mice than in mice humanized for PXR. To assess whether PXR is involved in the detoxification of DEX in the liver, we analyzed the consequences of high doses of the glucocorticoid on hepatotoxicity on different PXR genetic backgrounds. We also studied these effects in an additional mouse model in which functional mouse Cyp3a genes have been deleted. These strains exhibited different sensitivities to DEX, indicating a protective role of the PXR and CYP3A proteins against the hepatotoxicity of this compound.
Background: One of the most prominent neurobiological models of alexithymia assumes an altered function of the anterior cingulate cortex (ACC) as the crucial neural correlate of alexithymia. So far functional imaging studies have yielded inconclusive results. Therefore, we tested this hypothesis in healthy alexithymics and nonalexithymics in an event-related fMRI study.
Methods: Thirty high- and 30 low-alexithymic right-handed male subjects (selected by the 20-item Toronto Alexithymia Scale, TAS-20) were investigated with event-related fMRI using a picture viewing paradigm. The stimuli consisted of happy, fearful and neutral facial expressions (Ekman-Friesen) as well as positive, negative and neutral pictures from the International Affective Picture System.
Results: Contrasting the high-alexithymic with the low-alexithymic group we observed increased activation of the supragenual ACC for different emotional valences as well as for different emotional stimuli. Moreover, there was a positive correlation of the ACC with the individual TAS-20 scores but no correlations with the individual Beck Depression Inventory scores. Additionally, there was no difference in activity of the amygdala.
Conclusions: We demonstrated that the supragenual ACC is constantly activated more strongly in alexithymic subjects and that this activation is related to the symptoms of alexithymia and not to associated symptoms such as depression. Therefore, our findings support the hypothesis of an altered function of the ACC in alexithymia.