Simulation of cardiac cell-seeded membranes using the edge-based smoothed FEM
- We present an electromechanically coupled Finite Element model for cardiac tissue. It bases on the mechanical model for cardiac tissue of Hunter et al. that we couple to the McAllister-Noble-Tsien electrophysiological model of purkinje fibre cells. The corresponding system of ordinary differential equations is implemented on the level of the constitutive equations in a geometrically and physically nonlinear version of the so-called edge-based smoothed FEM for plates. Mechanical material parameters are determined from our own pressure-deflection experimental setup. The main purpose of the model is to further examine the experimental results not only on mechanical but also on electrophysiological level down to ion channel gates. Moreover, we present first drug treatment simulations and validate the model with respect to the experiments.
| Verfasserangaben: | Ralf FrotscherORCiD, Matthias GoßmannORCiD, Hans-Jürgen Raatschen, Aysegül Temiz ArtmannORCiD, Manfred StaatORCiD |
|---|---|
| ISBN: | 978-3-319-02534-6 ; 978-3-319-02535-3 |
| Titel des übergeordneten Werkes (Englisch): | Shell and membrane theories in mechanics and biology. (Advanced structured materials ; 45) |
| Verlag: | Springer |
| Verlagsort: | Heidelberg |
| Dokumentart: | Teil eines Buches (Kapitel) |
| Sprache: | Englisch |
| Erscheinungsjahr: | 2015 |
| Datum der Publikation (Server): | 30.09.2014 |
| Erste Seite: | 187 |
| Letzte Seite: | 212 |
| Link: | https://doi.org/10.1007/978-3-319-02535-3_11 |
| Zugriffsart: | campus |
| Fachbereiche und Einrichtungen: | FH Aachen / Fachbereich Chemie und Biotechnologie |
| FH Aachen / Fachbereich Medizintechnik und Technomathematik | |
| FH Aachen / Fachbereich Maschinenbau und Mechatronik | |
| FH Aachen / IfB - Institut für Bioengineering | |
| collections: | Verlag / Springer |
