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DNA-hybridization detection using light-addressable potentiometric sensor modified with gold layer
(2014)
This work presents a basic forecast tool for predicting direct normal irradiance (DNI) in hourly resolution, which the Solar-Institut Jülich (SIJ) is developing within a research project. The DNI forecast data shall be used for a parabolic trough collector (PTC) system with a concrete thermal energy storage (C-TES) located at the company KEAN Soft Drinks Ltd in Limassol, Cyprus. On a daily basis, 24-hour DNI prediction data in hourly resolution shall be automatically produced using free or very low-cost weather forecast data as input. The purpose of the DNI forecast tool is to automatically transfer the DNI forecast data on a daily basis to a main control unit (MCU). The MCU automatically makes a smart decision on the operation mode of the PTC system such as steam production mode and/or C-TES charging mode. The DNI forecast tool was evaluated using historical data of measured DNI from an on-site weather station, which was compared to the DNI forecast data. The DNI forecast tool was tested using data from 56 days between January and March 2022, which included days with a strong variation in DNI due to cloud passages. For the evaluation of the DNI forecast reliability, three categories were created and the forecast data was sorted accordingly. The result was that the DNI forecast tool has a reliability of 71.4 % based on the tested days. The result fulfils SIJ’s aim to achieve a reliability of around 70 %, but SIJ aims to still improve the DNI forecast quality.
The telecommunications industry is currently going through a major transformation. In this context, the enhanced Telecom Operations Map (eTOM) is a domain-specific process reference model that is offered by the industry organization TM Forum. In practice, eTOM is well accepted and confirmed as de facto standard. It provides process definitions and process flows on different levels of detail. This article discusses the reference modeling of eTOM, i.e., the design, the resulting artifact, and its evaluation based on three project cases. The application of eTOM in three projects illustrates the design approach and concrete models on strategic and operational levels. The article follows the Design Science Research (DSR) paradigm. It contributes with concrete design artifacts to the transformational needs of the telecommunications industry and offers lessons-learned from a general DSR perspective.
Conventional EEG devices cannot be used in everyday life and
hence, past decade research has been focused on Ear-EEG for mobile,
at-home monitoring for various applications ranging from
emotion detection to sleep monitoring. As the area available for
electrode contact in the ear is limited, the electrode size and location
play a vital role for an Ear-EEG system. In this investigation, we
present a quantitative study of ear-electrodes with two electrode
sizes at different locations in a wet and dry configuration. Electrode
impedance scales inversely with size and ranges from 450 kΩ to
1.29 MΩ for dry and from 22 kΩ to 42 kΩ for wet contact at 10 Hz.
For any size, the location in the ear canal with the lowest impedance
is ELE (Left Ear Superior), presumably due to increased contact
pressure caused by the outer-ear anatomy. The results can be used
to optimize signal pickup and SNR for specific applications. We
demonstrate this by recording sleep spindles during sleep onset
with high quality (5.27 μVrms).
This paper describes the concept of an innovative, interdisciplinary, user-oriented earthquake warning and rapid response system coupled with a structural health monitoring system (SHM), capable to detect structural damages in real time. The novel system is based on interconnected decentralized seismic and structural health monitoring sensors. It is developed and will be exemplarily applied on critical infrastructures in Lower Rhine Region, in particular on a road bridge and within a chemical industrial facility. A communication network is responsible to exchange information between sensors and forward warnings and status reports about infrastructures’health condition to the concerned recipients (e.g., facility operators, local authorities). Safety measures such as emergency shutdowns are activated to mitigate structural damages and damage propagation. Local monitoring systems of the infrastructures are integrated in BIM models. The visualization of sensor data and the graphic representation of the detected damages provide spatial content to sensors data and serve as a useful and effective tool for the decision-making processes after an earthquake in the region under consideration.
Clinical assessment of newly developed sensors is important for ensuring their validity. Comparing recordings of emerging electrocardiography (ECG) systems to a reference ECG system requires accurate synchronization of data from both devices. Current methods can be inefficient and prone to errors. To address this issue, three algorithms are presented to synchronize two ECG time series from different recording systems: Binned R-peak Correlation, R-R Interval Correlation, and Average R-peak Distance. These algorithms reduce ECG data to their cyclic features, mitigating inefficiencies and minimizing discrepancies between different recording systems. We evaluate the performance of these algorithms using high-quality data and then assess their robustness after manipulating the R-peaks. Our results show that R-R Interval Correlation was the most efficient, whereas the Average R-peak Distance and Binned R-peak Correlation were more robust against noisy data.
Humic substances possess distinctive chemical features enabling their use in many advanced applications, including biomedical fields. No chemicals in nature have the same combination of specific chemical and biological properties as humic substances. Traditional medicine and modern research have demonstrated that humic substances from different sources possess immunomodulatory and anti-inflammatory properties, which makes them suitable for the prevention and treatment of chronic dermatoses, allergic rhinitis, atopic dermatitis, and other conditions characterized by inflammatory and allergic responses [1-4]. The use of humic compounds as agentswith antifungal and antiviral properties shows great potential [5-7].
Pulmonary arterial cannulation is a common and effective method for percutaneous mechanical circulatory support for concurrent right heart and respiratory failure [1]. However, limited data exists to what effect the positioning of the cannula has on the oxygen perfusion throughout the pulmonary artery (PA). This study aims to evaluate, using computational fluid dynamics (CFD), the effect of different cannula positions in the PA with respect to the oxygenation of the different branching vessels in order for an optimal cannula position to be determined. The four chosen different positions (see Fig. 1) of the cannulas are, in the lower part of the main pulmonary artery (MPA), in the MPA at the junction between the right pulmonary artery (RPA) and the left pulmonary artery (LPA), in the RPA at the first branch of the RPA and in the LPA at the first branch of the LPA.
As a deduction from these results, we can conclude that proteins mainly in vitro, denaturate totally at a temperature between 57°C -62°C, and they also affected by NO and different ions types. In which mainly, NO cause earlier protein denaturation, which means that, NO has a destabilizing effect on proteins, and also different ions will alter the protein denaturation in which, some ions will cause earlier protein denaturation while others not.
Effectiveness of the edge-based smoothed finite element method applied to soft biological tissues
(2012)
Summary and Conclusions PCIs were clearly effective in terms of their antibacterial effects with the strains tested. This efficacy increased with the time the bacteries were exposed to PCIs. The bactericidal action has proved to be irreversible. PCIs were significantly less effective in shadowed areas. PCI exposure caused multiple protein damages as observed in SDS PAGE studies. There was no single but multiple molecular mechanism causing the bacterial death.
Masonry infill walls are the most traditional enclosure system that is still widely used in RC frame buildings all over the world, particularly in seismic active regions. Although infill walls are usually neglected in seismic design, during an earthquake event they are subjected to in-plane and out-of-plane forces that can act separately or simultaneously. Since observations of damage to buildings after recent earthquakes showed detrimental effects of in-plane and out-of-plane load interaction on infill walls, the number of studies that focus on influence of in-plane damage on out-of-plane response has significantly increased. However, most of the xperimental campaigns have considered only solid infills and there is a lack of combined in-plane and out-of-plane experimental tests on masonry infills with openings, although windows and doors strongly affect seismic performance. In this paper, two types of experimental tests on infills with window openings are presented. The first is a pure out-of-plane test and the second one is a sequential in-plane and out-of-plane test aimed at investigating the effects of existing in-plane damage on outof-plane response. Additionally, findings from two tests with similar load procedure that were carried out on fully infilled RC frames in the scope of the same project are used for comparison. Test results clearly show that window opening increased vulnerability of infills to combined seismic actions and that prevention of damage in infills with openings is of the utmost importance for seismic safety.
A new method for improved autoclave loading within the restrictive framework of helicopter manufacturing is proposed. It is derived from experimental and numerical studies of the curing process and aims at optimizing tooling positions in the autoclave for fast and homogeneous heat-up. The mold positioning is based on two sets of information. The thermal properties of the molds, which can be determined via semi-empirical thermal simulation. The second information is a previously determined distribution of heat transfer coefficients inside the autoclave. Finally, an experimental proof of concept is performed to show a cycle time reduction of up to 31% using the proposed methodology.
Physical interaction with small solar system bodies (SSSB) is key for in-situ resource utilization (ISRU). The design of mining missions requires good understanding of SSSB properties, including composition, surface and interior structure, and thermal environment. But as the saying goes "If you've seen one asteroid, you've seen one Asteroid": Although some patterns may begin to appear, a stable and reliable scheme of SSSB classification still has to be evolved. Identified commonalities would enable generic ISRU technology and spacecraft design approaches with a high degree of re-use. Strategic approaches require much broader in-depth characterization of the SSSB populations of interest to the ISRU community. The DLR-ESTEC GOSSAMER Roadmap Science Working Groups identified target-flexible Multiple Near-Earth asteroid (NEA) Rendezvous (MNR) as one of the missions only feasible with solar sail propulsion, showed the ability to access any inclination and a wide range of heliocentric distances as well as continuous operation close to Earth's orbit where low delta-v objects reside.
Traglast- und Einspielanalysen sind vereinfachte doch exakte Verfahren der klassischen Plastizitätstheorie, die neben ausreichender Verformbarkeit keine einschränkenden Voraussetzungen beinhalten. Die Vereinfachungen betreffen die Beschaffung der Daten und Modelle für Details der Lastgeschichte und des Stoffverhaltens. Eine FEM-basierte Traglast- und Einspielanalyse für ideal plastisches Material wurde auf ein kinematisch verfestigendes Materialgesetz erweitert und in das Finite Element Programm PERMAS implementiert. In einem einfachen Zug-Torsionsexperiment wurde eine Hohlprobe mit konstanter Torsion und zyklischer Zugbelastung beansprucht, um die neue Implementierung zu verifizieren. Es konnte gezeigt werden, dass die Einspielanalyse gut mit den experimentellen Ergebnissen übereinstimmt. Bei Verfestigung lassen sich wesentlich größere Sicherheiten nachweisen. Dieses Potential bedarf weiterer experimenteller Absicherung. Parallel dazu ist die Eisnpieltheorie auf fortschrittliche Verfestigungsansätze zu erweitern.
Electromechanical model of hiPSC-derived ventricular cardiomyocytes cocultured with fibroblasts
(2018)
The CellDrum provides an experimental setup to study the mechanical effects of fibroblasts co-cultured with hiPSC-derived ventricular cardiomyocytes. Multi-scale computational models based on the Finite Element Method are developed. Coupled electrical cardiomyocyte-fibroblast models (cell level) are embedded into reaction-diffusion equations (tissue level) which compute the propagation of the action potential in the cardiac tissue. Electromechanical coupling is realised by an excitation-contraction model (cell level) and the active stress arising during contraction is added to the passive stress in the force balance, which determines the tissue displacement (tissue level). Tissue parameters in the model can be identified experimentally to the specific sample.
Funktionsprinzip Emissionsrechtehandel, Betroffene Anlagen und Branchen, Erstverteilung der Emissionsrechte, Bereits erbrachte Emissionsreduktionen (early actions), Ausstieg von betroffenen Unternehmen (opt-out), Teilnahme von nicht betroffenen Unternehmen, Einsatz von Biobrennstoffen, Erfassung und Dokumentation der Emissionen
The results of a statistical investigation of 42 fixed-wing, small to medium sized (20 kg−1000 kg) reconnaissance unmanned air vehicles (UAVs) are presented. Regression analyses are used to identify correlations of the most relevant geometry dimensions with the UAV’s maximum take-off mass. The findings allow an empirical based geometry-build up for a complete unmanned aircraft by referring to its take-off mass only. This provides a bridge between very early design stages (initial sizing) and the later determination of shapes and dimensions. The correlations might be integrated into a UAV sizing environment and allow designers to implement more sophisticated drag and weight estimation methods in this process. Additional information on correlation factors for a rough drag estimation methodology indicate how this technique can significantly enhance the accuracy of early design iterations.
Enceladus explorer - A maneuverable subsurface probe for autonomous navigation through deep ice
(2012)
Working paper distributed at 2nd Annual Next Generation Telecommunications Conference 2009, 13th – 14th October 2009, Brussels 14 pages Abstract Governments all over Europe are in the process of adopting new broadband strategies. The objective is to create modern telecommunications networks based on powerful broadband infrastructures". In doing so, they aim for innovative and investment-friendly concepts. For instance, in a recently published consultation paper on the subject the German regulator BNetzA declared that it will take “greater account of … reducing risks, securing the investment and innovation power, providing planning certainty and transparency – in order to support and advance broadband rollout in Germany”. It further states that when regulating wholesale rates it has to be ensured that “… adequate incentives for network rollout are provided on the one hand, while sustainable and fair competition is ensured on the other”. Also an EC draft recommendation on regulated network access is about to set new standards for the regulation of next generation access networks. According to the recommendation the prices of new assets shall be based on costs plus a projectspecific risk premium to be included in the costs of capital for the investment risk incurred by the operator. This approach has been criticised from various sides. In particular it has been questioned whether such an approach is adequate to meet the objectives of encouraging both competition and investment into next generation access networks. Against this background, the concept of “long term risk sharing contracts” has been proposed recently as an approach which does not only incorporate the various additional risks involved in the deployment of NGA infrastructure, but has several other advantages. This paper will demonstrate that the concept allows for competition to evolve at both the retail and wholesale level on fair, objective, non-discriminatory and transparent terms and conditions. Moreover, it ensures the highest possible investment incentive in line with socially desirable outcome. The paper is organised as follows: The next section will briefly outline the importance of encouraging competition and investment in an NGA-environment. The third section will specify the design of long term risk sharing contracts in view of achieving these objectives. The fourth section will examine potential problems associated with the concept. In doing so a way of how to deal with them will be elaborated. The last section will look at arguments against long term risk sharing contracts. It will be shown that these arguments are not strong enough to build a case against introducing such contracts.
In Anbetracht weltweit zunehmend strengerer klimapolitischer
Ziele steigt auch der Druck für Nutzfahrzeughersteller, effizientere und umweltfreundlichere
Technologien zu entwickeln. Den Blick bei der Bewertung dieser
ausschließlich auf die Fahrzeugnutzung zu richten, ist längst nicht mehr zufriedenstellend.
Im Rahmen dieser Analyse wird ein gegenwärtig auf dem Markt erwerblicher
und in deutschen Städten bereits seit Jahren betriebener Hybridbus
energetisch und ökologisch mit einem konventionell angetriebenen, nahezu baugleichen
Modell entlang des Lebensweges bewertet.
Nach Definition von Ziel und Untersuchungsrahmen wird ein Überblick auf bereits
durchgeführte Lebenszyklusanalysen zu Hybridbussen im Stadtverkehr gegeben
und Schlussfolgerungen für die anschließende Analyse abgeleitet. Diese
wird im Rahmen einer energetischen und ökologischen Bewertung beider Produktsysteme
anhand der Parameter "Primärenergieeinsatz" und "CO2äq Emissionen"
praktiziert. Der Fahrzeugrumpf beider Fahrzeuge des gleichen Modells
wird dabei als einheitlich angenommen, sodass bei dem Vergleich der Herstellung
vereinfacht nur die sich unterscheidenden Komponenten des Antriebstranges
berücksichtigt werden. Die Resultate der Wirkungsabschätzung werden als
Differenz des Hybridbusses gegenüber dem Referenzfahrzeug über die einzelnen
Lebenszyklusphasen dargestellt. Schließlich werden Prognosen getroffen, ab
welcher Strecke die bei der Herstellung erzeugten höheren CO2äq Emissionen
des Hybridantriebstranges gegenüber dem Referenzmodell ausgeglichen werden.
Energiebilanzen und -potenziale von Abwasseranlagen : Vorstellung neuer Untersuchungsvorhaben in NRW
(2010)
Entscheidungsunterstützung bei der Gestaltung der betrieblichen Energieversorgung und -nutzung
(1998)
Entwicklung einer Qualitätssicherung für das Laserstrahlschweißen im Vakuum mittels Bildverarbeitung
(2019)
Beim Ausbau nachhaltiger, regenerativer Energieversorgung hat die Umwandlung von organischer Biomasse in Biogas ein großes Potential. Der zugrundeliegende, komplexe biologische Prozess wird noch immer unzureichend verstanden und bedarf systematischer Untersuchungen der Prozessparameter, um einen hohen Ertrag bei guter Gasqualität zu ermöglichen. Die Fragestellungen zur Entschlüsselung des Prozesses sind sowohl verfahrenstechnischer als auch mikrobiologischer Natur. Aus mikrobiologischer Sicht ist die Kenntnis der tatsächlich beteiligten prozesstragenden Mikroorganismen von erheblicher Bedeutung, aus verfahrenstechnischer Sicht die Kenntnis der physikalischen und chemischen Faktoren, welche die mikrobiologischen Prozesse und kontrollieren. Im Zusammenspiel aller dieser Parameter wird die Biogasbildung befördert oder behindert, bis zum Abbruch des Prozesses.
Eine mögliche Kontrollmethode ist die Messung der metabolischen Aktivität prozesstragender Organismen.
Diese soll, beruhend auf fundierten Prozessdaten, gewonnen durch eine Parallelanlage, mit einem lichtadressierbaren potentiometrischen Sensor-System (LAPS) realisiert werden. Dieser Sensor ist in der Lage, pH-Wert-änderungen zu detektieren, die durch den Stoffwechsel der auf dem Chip immobilisierten Organismen hervorgerufen werden, um eine Online-Überwachung von Biogasanlagen zu ermöglichen.
Obwohl es eine Vielzahl von Einführungskonzepten für ITSM gibt, hat sich bisher keines dieser Konzepte auf breiter Linie durchgesetzt. Das gilt in erhöhtem Maße für ITSM-Einführungskonzepte für KMU, wohl nicht zuletzt aufgrund der Tatsache, dass der Mehrwert von ITSM für KMU aufgrund der geringeren Größe der IT-Organisationen nur entsprechend schwieriger generiert werden kann.
Mit diesem Beitrag wird ein Einführungskonzept für ITSM in KMU systematisch hergeleitet. Dafür wurden zunächst die Treiber und Barrieren von ITSM untersucht, um daraus ein umfassendes Wirkmodell zu entwickeln. Da mit diesem Wirkungsmodell die Einflussfaktoren auf den Erfolg von ITSM in KMU deutlich werden, konnte auf dieser Basis ein Einführungskonzept abgeleitet werden, welches insbesondere die positiven Effekte unterstützt bzw.
verstärkt.
Entwicklung eines Kletterroboters zur Diagnose und Instandsetzung von Windenergieanlagen (SMART)
(2016)
In diesem Paper wird die Entwicklung und Evaluation eines grafischen Regeleditors für das Erstellen von „Smart Living Environments“-Services vorgestellt. Dafür werden zunächst die Deduktion und Implementierung des grafischen Regeleditors erläutert. Anschließend wird eine Probandenstudie vorgestellt, in welcher der Mehrwert bezogen auf die Aspekte Zeit, Fehleranfälligkeit und Gebrauchstauglichkeit festgestellt wird.